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1、DRUGREPORT:argatroban.SUMMARY.DrugNameargatrobanCompanyMitsubishi-TokyoPharmaceuticalsInc(MitsubishiChemicalHoldingsCorp)HighestDevLaunchedStatusFDAApprovedCoronaryArteryThrombosis,InPatientsWithOrAtRiskForHeparin-InducedThrombocytopenia;Prophylaxis-PercutaneousCoronaryI
2、ntervention(Adult),Heparin-InducedThrombocytopenia;TreatmentAndProphylaxis-Heparin-InducedThrombocytopeniaWithThrombosis(Adult)TherapyAreasThrombosis;Heparininducedthrombocytopenia;Myocardialinfarction;Angina;Thromboembolism;Deepveinthrombosis;Cerebralinfarction;Cerebrov
3、ascularischemiaActionsFactorIIaantagonist;Plateletaggregationinhibitor;CoagulationinhibitorTechnologiesInjectableformulation;Smallmoleculetherapeutic;ParenteralformulationunspecifiedTargetFactorIIaUpdatedate29-DEC-2010ReasonforMinorEditorialAmendmentupdate.OVERVIEW.Mitsu
4、bishiPharma(formerlyMitsubishi-Tokyo,nowMitsubishiTanabe)andDaiichiSeiyaku(nowDaiichiSankyo)developedandlaunchedargatroban(MCI-9038,MD-805,Acova,Slonnon,Novastan,Argatra,Arganova),anon-protein,arginine-relatedthrombininhibitor.TheproductisindicatedinJapanasaninjectabletr
5、eatmentofchronicarterialobstructioncausedbythromboembolismandforacutecerebralthrombosis[423717].MitsubishiandlicenseesEncysive(formerlyTexasBiotechnology,nowpartofPfizer)andSmithKlineBeecham(nowGlaxoSmithKline)havealsodevelopedthedrugforuseinheparin-inducedthrombocytopen
6、ia(HIT);inthismarket,thedrugindicatedasananticoagulantforprophylaxisortreatmentofthrombosisinpatientswithheparin-inducedthrombocytopenia(HIT),aswellasinpatientswithoratriskforHITundergoingpercutaneouscoronaryintervention(PCI)[1099746]..ArgatrobanhasbeenavailableinJapanfo
7、rthromboembolismsince1990[166797].ByNovember2000,thedrughadbeenlaunchedintheUSforHIT[389484].ItwasadditionallymadeavailableforHITinJapaninJuly2008[934660];andinseveralEuropeancountriesandCanadaby2009[1009181],[999725].MitsubishiandlicenseeHyundailaunchedthedrugforcerebra
8、linfarctioninJapanandKoreain2001[423717],[1009181]..PhaseIIdevelopmentforcerebralinfarctionwasunderwayi
