腹膜透析液添加丹参酮ⅡA对腹膜水清除的影响

《腹膜透析液添加丹参酮ⅡA对腹膜水清除的影响》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·2380·江苏医药2011年lO月第37卷第2O期Jian~suMedJ，October201l，Vol37，No．20●论著腹膜透析液添加丹参酮ⅡA对腹膜水清除的影响孙垮张苗蒋春明【摘要】目的观察在腹膜透析液(PDS)中添加丹参酮ⅡA对腹膜透析(PD)患者腹膜水清除的影响。方法78例置管3个月的PD患者随机均分为两组：试验组在PDS中添加丹参酮ⅡA注射液10mg／2L；对照组PDS中不加药。均行持续非卧床PD治疗。用药3周前后行标准腹膜平衡试验(PET)及Mini—PET。结果与PD前比较，试验组用药后总水清

2、除、自由水清除、4-h尿素氮、肌酐MTAC值均较用药前明显升高(P<0．05)，小孔水清除、葡萄糖D／Do均较用药前明显降低(P

3、npatientsundergoingcontinuousambulatoryperitonealdialysisSUNCheng，ZHANGMiao，JIANGChunming．DepartmentofNephrology，AffiliatedDrumTowerHospital，NanjingUniversityMedicalCollege，Nanjing210008，CHlNA[Abstract]ObjectiveToinvestigatetheimpactoftanshinoneⅡAontheefficac

4、yofperitonealdialysis(PD)inthepatientsundergoingcontinuousambulatoryperitonealdialysis(CAPD)．MethodsAfterPDcatheterhadbeeninsertedfor3months，78stableCAPDpatientswereequallyrandomizedintotWOgroupsofA(addedtanshinone1IA10mg／2Lindialysissolution)andB(didnotaddas

5、thecontro1)Peritonealdialysiswaslastedfor3weeks．Peritonealequilibrationtest(PET)andmini-PETweremeasuredatthebeginningandthreeweekslater．Themasstransferareacoefficients(MTACs)ofurea，creatinineandvolumeofultrafiltrationwerecalculatedandcompared．ResultsComparedt

6、obefore，totalultrafiltration．freewatertransportandtheMTACSofureaandcreatinineafterPDweresignificantlyincreased，butD／DoofglucoseandultrafiltrationthroughthesmallporesweredecreasedingroupA(P<0．05)．NosuchdifferenceswerefoundingroupBConclusionTheadditionoftanshin

7、oneⅡAintoperitonealdialysissolutioncannotonlyincreaseperitonealtranspo~ofureaandcreatinine，butalsoincreasetotalultrafiltrationandfreewatertransportinthepatientsundergoingcontinuousambulatoryperitonealdialysis．[Keywords]TanshinoneIA；PeritonealdialysislJiangsuM

8、edJ，October201l，37(20)：2380．2382．1腹膜透析(PD)是终末期肾脏病患者常用的替加黄芪、川芎嗪、丹参等药物在增加溶质清除的同时代治疗方法之一。但随着PD时间的延长，腹膜功并不减少甚至可以增加腹膜的超滤L3]。本研究通过能衰竭所导致的腹膜超滤减少、溶质清除减低已成在PDS中添加丹参酮ⅡA，借助腹膜对水和溶质清为PD技术性失败的最重要原因[1]。