突触损伤在氟致神经毒性中的作用

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1、分类号学号D201578087学校代码10487密级博士学位论文突触损伤在氟致神经毒性中的作用学位申请人：陈静雯学科专业：劳动卫生与环境卫生指导教师：王爱国教授答辩日期：2018年05月25日HuazhongUniversityofScienceandTechnologyDoctoralDissertationTheroleofsynapticimpairmentinfluoride-inducedneurotoxicityCandidate:JingwenChenMajor:Occupational

2、andEnvironmentalHealthSupervisor:ProfessorAiguoWangDate：2018-05-25华中科技大学博士学位论文1华中科技大学博士学位论文目录英文缩写词及中英对照..................................................................................................3摘要.................................................

3、.................................................................................5Abstract.............................................................................................................................8前言...................................

4、.............................................................................................12第一部分突触损伤、BDNF/TrkB通路异常和ERK/CREB通路激活在氟致SD大鼠发育神经毒性中的作用............................................................................................171材料和方法......

5、....................................................................................................172结果......................................................................................................................283讨论.........................

6、.............................................................................................36第二部分磷酸化ERK1/2介导的BDNF/TrkB通路异常在氟致SH-SY5Y细胞突触损伤中的作用.............................................................................................................

7、...401材料和方法..........................................................................................................412结果......................................................................................................................473讨论........

8、..............................................................................................................54总结...................................................................................................................