有机合成(英)a

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1、HomewarkⅠ.TranslatethefollowingtermintoChinese(10Points)Acid-catalyzedcondensationPericyclicreactionPrimaryalkylhalideNucleophilicadditionEthyleneoxideMonosubstitutedbenzeneDiazogroupBeckmannrearrangementDithioacetalPotassiumpermanganateⅡ.Selectthecorrectchoice,onlyonechoiceiscorrect(

2、20Points).1．Thecommonlyusedbases,inorderofdecreasingbase-strength,are(a)NH2－>OH－>OMe－>EtO－(b)EtO－>OH－>R3N>NH2－(c)NH2－>Ph3C－>MeO－>OH－(d)NH2－>Me3CO－>MeO－>OH－2Theconditionforfollowingreactionis:(a)ABIN(b)base(c)hn(d)heat3．WhichofthefollowingcompoundsisinerttowardsaminesorammoniainSN2proc

3、esses?(a)(b)CH3CH2Br(c)CH2=CHCH2Br(d)4.Whichofthefollowingcompoundsisenol?(a)(b)(c)(d)CH3CH2OH5.Asshowinthefigure,Yisasubstituent,whichofthefollowingsubstitutents(Ygroup)isthemostactivinggroupinElectrophilicAromaticSubstitution?(a)OR(b)Br(c)CN(d)CH36.Thereactionbelongstowhichofthefoll

4、owingreaction?(a)ElectrophilicAromaticSubstitution(b)Friedel－Craftsreaction(c)Chloromethylationreaction(d)NucleophilicAromaticSubstitution7.Thereactionviawhichofthefollowingintermediates?(a)anion(b)cation(c)freereadical(d)benzyne8..Asshowinthefollowingreaction,thearylgroupprovideanchi

5、mericassistancetothereaction.Whichofthesubstituentsinthearomaticringgiverisetogreatestrateofmigration?(a)p－NH2(b)p－Br(c)p－CN(d)p－CO2R9.Theconditionforthereactionis:(a)H2SO4(b)NaOH(c)H2O(d)CF3CO3H10.WhichofthefollowingcompounddonotreactwithRMgBr?(A)CH3CHO(b)CH3COCH3(c)(d)CH3OCH3Ⅲ.Write

6、themajorproductofthefollowingreaction(30Points).1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.Ⅳ.Suggestreasonablemechanismsforeachofthefollowingreactions(20Points).1.2.3.4.V.Suggestreactionsequencesthatmightaccomplishthedesiredsynthesis(20Points).1.2.3.4.5.