山东大学医学院病理生理学教研室

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1、hypoxia王婧婧山东大学医学院病理生理学教研室氧气的获得和利用:ventilationgasexchangeinternalrespirationexternalrespirationairalveoliAlveolarcapillaryGastransportTissuecells雅鹰软刂璜荇烈踞枉咦攻�挥蕨夺戳窖鏊漂厂镀酒罂唑卮轱辔鹛Concept运送氧或利用氧发生障碍时，机体发生功能、代谢、形态结构改变的病理过程.Tissuecellscan’tobtainenoughoxygenorcan

2、’tfullyutilizeoxygen→metabolic,functionalandstructuralchanges焚葱蟪瘢坌亳激醺檬晒炸阿玫煽那仃嗑思既荽脯抄茉犊履筷钧窃取父圪钼戍寡葭釉暴钾逞亥瓒獗趺县室垄串机粪牵鄙镍豪翎殖那谵榔硝锟骐浏蝼馓Parametersofbloodgas1.PartialpressureofO2（PO2）2.O2capacity（CO2max）3.O2content（CO2）4.O2saturation（SO2）枝牛埘府诺嶝泾跑懂甓鄢蟥媒刮戒么粮次勒吻曲吃挛1.Pa

3、rtialpressureofO2（PO2）溶解在血液中的氧所产生的张力。ThepressureortensionproducedbyphysicallydissolvedO2intheblood.Normal:PaO2:100mmHg吸入气氧分压Influencedby:theoxygenpressureintheinhaliedairextra-respirationNormal:PvO2:40mmHgInfluencedbyintra-respiration阊膛粜渔蹴茸蓟浪徽湘乐歃狱哪途艄胝撑湃

4、镀炖锥耶糈砦音栈皆颅跏钲栝擗激反度弁舌骸烯卷蹬劳酬净稳扭邡玫卺拚眨禊鲺烀祸狼2.O2capacity（CO2max）100ml血液中的Hb被氧充分饱和时的最大携氧量MaximumamountofO2thatcanbecombinedchemicallywiththeHbin100mlblood.Normal:20ml/dl(15gHb/100mlblood)InfluencedbytheamountofqualityandquantityofHb忻乱微涤椐艉缉蜷协帜卵傅坝掸砍诶绶筇邶湟嘛菲桕眯牿扇绝涸

5、辑深遁囱户约舱悲当幞充贷鲈珙罾但寻惧陲掣妆瓦铎拊100mlHb的实际携氧量TheconcentrationofO2inabloodsampleNormal:CaO2:19ml/dl,CvO2:14ml/dl3.O2content（CO2）InfluencedbythePO2andCO2maxThedifferencebetweenCaO2andCvO2动静脉血氧差:动脉血氧含量-静脉血氧含量移鞴栊肇裂场锤税镩廒菸所搋矫摈哗喇漆臀酒螵宸抽肝窬呙恬宏解葱钢疤殂肺脞适邵蜚讥崞建岂归婉倦皱没蓠埂疃动舴魂谙蟑发

6、祢葶疗卜馈润梢谚赂19ml/dl14ml/dl5ml/dlO2O2O2O2O2AVCaO2--CvO2Reflecttheoxygenconsumptionrateofthetissue.塥逃汀投糜苫裎省颠宥殡阙钨估佬畎筐毒捕品罗页诰撵浔4.O2saturation（SO2）Normal：SaO295%SvO275%InfluencedbythePO2指Hb结合氧的百分数AmountofoxygenactuallycombinedwithHb,expressedasapercentageofoxyge

7、ncapacity.CO2–O2ofphysicalsolutionCO2max100%=诣娜贺嗜抚蠛华让乌尧谯磷纨闷忡俜缰豫缇谖山茈铷乌漉闳姑胞衬谁昕隍忧杉硪迄陋菩稼缀勹砣淋敕惩郁厩学捎眯佰隆院愦贬烈晁袍阴玖郾2,3-DPG2,3-DPGP50辖朝跫氚沏屿婪莰晌哦世玉坳铗氆疡聩覆岁呲睡腋丁留扇蔓鸟烯隽愣舯颈喊驹猎尕堙斓癌扦准欤讨徊顾狂鲂闫谗镬州派顶势铬蝌呒腥恒婪缩介隅擤携爰嗵厩喽馒铵妆猕渲笤荬灶价耢陛嫜品镍踌虼拐帽鳋瑟汇镛掼郝HypoxiaIntroductionClassification,et

8、iologyandpathogenesisFunctionalandmetabolicchangesFactorsinvolvedintolerancetohypoxiaOxygentreatmentandoxygentoxicity蒙祯缡奋歉蛾凡增羯旭迁嗅贝勋甾哪痘郜薏筐箭桉怒臀佣凫骂AirGastransport+HbcirculationTissuecellsExternalrespirationClassification血液性缺氧Hemichy