奥美沙坦酯对轻、中度高血压的降压疗效及对踝臂指数的影响

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1、·中文论著摘要·奥美沙坦酯对轻、中度高血压的降压疗效及对踝臂指数的影响目的探讨奥美沙坦酯对轻中度高血压降压疗效及对踝臂指数的影响。材料和方法2008年7月．11月的我院门诊、住院的40例高血压患者，将其随机分为奥美沙坦组和氨氯地平组，治疗8周，检测血常规、尿常规、生化、心电图，记录血压、心率变化，并在治疗开始及结束后检测24hABPM和ABI。实验结果8周末，两组治疗前后诊室随机血压、24h、白昼及夜间平均收缩压及舒张压均显著下降(P

2、可持续24小时，收缩压及舒张压的降压谷峰比均>50％。两组治疗8周ABI较前分别有所升高，统计学上有显著差异。两组间比较无统计学差异。结论奥美沙坦酯治疗轻中度高血压安全有效，谷峰比满意，能够24小时平稳降压，且长期应用可改善动脉硬化。关键词奥美沙坦酯片；原发性高血压；动态血压监测；踝臂指数·英文论著摘要·AntihypertensiveeffectsandinfluenceofABIinmildandmoderateprimaryhypertensiontreatedwitholmesartanmedo

3、xomiltabletobjectiveTopredicttheeffectofolmesartanmedoxomilinthetreatmentofpatients、析mmildtomoderateprimaryhypertensionandtheeffectofimprovingABI．MethodsArandomizedtrialwasperformed．FromJulytoNovemberin2008，fortypatients、析tllmildtomoderateprimaryhyperten

4、sionwererandomlydevidedintoolmesartangroupandamiodipinegroup．Thechangesofbloodpressure，heartrate，electrocardiogram，bloodandurinarylaboratoryexaminationwereobserved．The24-hourambulatorybloodpressuremonitoringandABlwereinvestigatedattheendofplaceboandtreat

5、mentpedod．ResultsAfter8wktreatment，CBP，meal]．systolicbloodpressure(SBP)andmeandiastolicbloodpressure(DBP)of24h，daytimeandnight，weresignificantlyreduced(P<0．05)，whilenosignificantdifferenceWasfoundinheartrate．Thetotaleffectiverateofthetwogroupswere85％．The

6、antihypertensiveeffectofolmesartanCancoverover24hours．Thetroughtopeakratiosforsystolicanddiastolicbloodpressurebyolmesartanwereallmorethan50％．ABIWasimprovedintwogroups．Therewerenosignificantdifferencesintwogroups．ConclusionOlmesartanissafeandeffectivefor

7、the仃eatmentofmildtomoderatehypertension．Thetroughtopeakratioissatisfied．TheeffectofolmesartanoncedailyCanmaintainfor24hours．UsingolmesartanlongerCanimproveartheriosclerosis．2Keywordolmesartanmedoxomiltablet；primaryhypertension；ambulatorybloodpressuremoni

8、toring；anklebrachialindex3·英文缩略语·缩略语英文全称中文全称ABIallklebrachialindex踝臂指数啪外周动脉疾病ABPMambulatorybloodpressure动态血压监测monitoring24hmSBP24hmeansystolicblood24小时平均收缩压pressure24hmDBP24hmeandiastolicblood24小时平均舒张压pressure24hmPP24hmean