间质性膀胱炎膀胱黏膜组织病理和超微病理的相关研究

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1、75oTianjinMedJ，Sep2010，Vol38No9间质性膀胱炎膀胱黏膜组织病理和超微病理的相关研究张卫史刚刚韩瑞发摘要目的：探讨间质性膀胱炎(Ic)膀胱黏膜上皮组织病理学与超微病理的改变与特征。方法：收集16例女性Ic患者的膀胱黏膜标本为Ic组，16例女性输尿管结石患者标本为对照组。Ic患者临床表现主要为尿频、尿急、膀胱充盈后疼痛及排尿后疼痛减轻，尿常规与尿培养阴性，盆腔症状评分(PUF)均在15分以上，钾离子试验阳性，膀胱镜检查可见膀胱黏膜多发性球状出血点。采用普通光镜和透射电镜的方法观察膀胱黏膜上皮和黏膜肥大细胞浸润及脱颗粒情况。结果：光

2、镜下Ic患者膀胱黏膜上皮发生断裂或缺失，黏膜有大量肥大细胞浸润，肥大细胞计数同正常对照组比较差异有统计学意义(P

3、erstitialCystitisZHANGWei，SHIGanggang，HANRuifaTheSecondHospitalofTianjinMedicalUniversity,TianjinInstituteofUrologicSurgery,Tianjin,300211，ChinaAbstractObjective：Toobservethehistopathologicalanduhramicropathologicalcharacteristicsofbladdermucosainpatientswithinterstitialcystitis(

4、IC)．Methods：Bladdermucosalspecimenswereharvestedfrom16patientswithICand16normalcontrols．Twogroupswerematchedingenderandage．PatientswithICwerecharacterizedbybladderpain，urinaryfre—quencyandpelvicpainassociatedwithdyspareunia．Theywerenegativeinurinalysisandurineculture．Thepatientsw

5、eredi．agnosedaccordingtothenationalinstituteofdiabetesanddigestiveandkidneydiseases(NIDDK1criteria．Allpatientshadthepelvicpainandurinary／frequency(PUF1scores>l5，potassiumsensitivitytest(PST)positiveandglomerulationsincystoscopy．Biopsywasobservedthroughlightmicroscopeandtransmissi

6、onelectronmicroscopeintwogroups．Results：Therewerere-gionswhichappearedtobedetachedthroughlightmicroscopeinbladdermucosaofICpatients．TherewerealargenumberofmastcellsinfiltratinginmucosalayerobservedthroughlightmicroscopeinICpatients，whichwassignificantlydifferenteom—paredwiththato

7、fcontrolgroups(P<0．05)．Therewereregionsbetweencellsinwhichportionsofadjacentumbrellaceilsap—pearedtobedetachedinbladdermucosaofICpatients．MastcelldegranulationwasobservedbyelectronmicroscopeinICgroup．whichwassignificantlydifferentcomparedwiththatofcontrolgroupsfP<0．05)．Conclusion

8、：Itplaysanimportantroleinthepathogenesis