抗原特异性免疫治疗对花粉症的长期疗效

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1、抗原特异性免疫治疗对花粉症的长期疗效作者：林小平，何韶衡，高军，迟秀丽【关键词】表位Longtermeffectevaluationofantigenspecificimmunotherapyforpatientswithpollenallergy　　【Abstract】AIM:Toevaluatetheeffectivenessofallergenspecificimmunotherapy(SIT)intreatingpatientswithpollinosis.METHODS:Atotalof235patientswithpollenallergywererecr

2、uitedintothestudyandwererandomlydividedintotwogroups:SITgroupwithsubgroups:allergicrhinitisgroup(n=65)andallergicrhinitis+asthmagroup(n=60),andST(symptomatictherapy)groupwithsubgroups:allergicrhinitisgroup(n=56)andallergicrhinitis+asthmagroup(n=54).Fortythreehealthyindividualsweretakena

3、scontrols.ThelevelsofserumtotalIgE(tIgE),specificIgE(sIgE)andeosinophilcantionicprotein(ECP)weredeterminedwithUniCAPsystem.IgGwasmeasuredandeosinophilnumberswerecounted.Theabovementionedindices,lungfunctionindices,symptomaticscoreandskintestresultswerecomparedbetweenthetwogroupsbeforean

4、daftertreatment.9RESULTS:TheelevatedlevelsoftIgE,sIgE,ECPandtIgE:IgGintheseraandeosinophilcountsinperipheralbloodofthepatientsweresignificantlyreduced,whereasthelevelofIgGincreasedfollowingtreatmentwithSIT.Lungfunction,symptomaticscoreandskintestresultallimprovedafterthetreatmentwithSIT

5、.Approximately40%ofthepatientswereclinicallycuredand57.7%respondedtoSIT.Only2.3%remainedunchangedandabout8.9%patientssufferedsideeffectsofSIT.NochangesintheabovementionedindiceswereobservedinSTgroup.CONCLUSION:SITcanimprovethesymptomsofthepatientswithallergicrhinitisandasthmabyincreasin

6、gthelevelofserumIgG,decreasingtheIgEandinhibitingtheeosinophilcountsinperipheralblood.　　【Keywords】epitopes;immunotherapy;hayfever;ImmunoglobulinE(IgE)　　【摘要】目的：探讨抗原特异性免疫治疗(specificimmunotherapy,SIT)对花粉症患者的疗效及作用机制.方法：选择对夏秋季豚草(Ragweed)和蒿草(Atremisavulgaris)过敏的花粉症患者（过敏性鼻炎或哮喘）235例，随机分为SIT组：包括

7、过敏性鼻炎组（n=65）;过敏性鼻炎+哮喘组（n=60）；对症治疗组（symptomatic9therapy,ST）,同样包括过敏性鼻炎组（n=56），和过敏性鼻炎+哮喘组（n=54）.健康对照组（n=43）.应用UniCAPsystem免疫荧光法、双抗体夹心ELISA法、放射比浊法和瑞氏染色法分别测定血清特异性IgE（sIgE）、总IgE（tIgE）、嗜酸性粒细胞阳离子蛋白（ECP）、IgG水平和外周血嗜酸性粒细胞（Eos）计数.分别比较二组治疗前、后上述各种参数、肺功能指标、症状评分和皮肤试验指数的变化.结果：治疗前，患者血清sIgE、tIgE、