欢迎来到天天文库
浏览记录
ID:36721664
大小:1.31 MB
页数:28页
时间:2019-05-14
《CD117CD34在急性白血病中的表达及临床意义研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、摘要目的:研究CDll7/CD34在急性淋巴细胞性白血病(ALL)和急性髓性白血病(AML)患者骨髓细胞中的表达,以探讨CDl17/CD34对于成人急性白血病(AL)诊断及鉴别诊断中的应用价值;并结合AML患者治疗疗效,评价CDll7/CD34共表达与AML患者预后的关系。方法:采用流式细胞术(flowcytometery,FCM)分别检测76例ALL和83例AML初诊患者骨髓CDll7/CD34的阳性表达率:比较ALL和AML患者CDll7/CD34表达的差异,设立20例健康成人为对照组。监测AML患者疗效,比较CDll7/CD34共表达AML患者与非CDll7/CD34表达AML
2、患者治疗效果及预后差异。结果:正常对照组中CDll7/CD34无共表达,ALL组中CDll7/CD34共表达率为6.6%(5/76),与对照组o%(o/20)无显著性差异(#=1.388,P>0.05)。AML中CDl17/CD34共表达率为49.4%(41/83)与对照组有显著差异(Z2=10.213,P<0.001),与ALL也有显著差异(Z=35.377,P<0.01);CDl17/CD34在AML各亚型之间共表达无明显差异,而Mo"M2的表达率则明显高于M。~M7;34例AML患者中CDll7/CD34共表达患者12例患者获得完全缓解,完全缓解率29.4%,明显较非CDll7
3、/CD34共表达患者67.7%(21/31)低,统计学显示有差别(P<0.05)。结论:CDl17/CD34可作为急性白血病的MICM分型诊断之髓系免疫学标志,用以AML的f临床诊断和鉴别诊断,并可用于协助AML亚型诊断;CDll7/CD34共表达患者完全缓解率(cR)率低,死亡率高,可作为预后判断的指标之一。关键词:急性白血病;流式细胞术;白细胞分化抗原IIAbstractABSTRACTOBJECTIVE:ThisstudytheexpressionofCDl17/CD34inboneonacutelymphoidleukemia(ALL)patientsandacutemyel
4、oidleukemia(AML)patients,toexplorethevalueoftheexpressionofCD17/CD34Ondiagnosisandantidiastoleinadultpatientswithacuteleukemia(AL).follow-upvisitingAMLpatients,toevaluatetherelationbetweenCD17/CD34CO,expressionandtheprognosisofAMLpatients.METHODS:Flowcytometery(FCM)wasusedtodetectthepositiveexp
5、ressionrateofCD17/CD34inboneof57patientswithALLand64patientswithAML.ThedifferencebetweentheratesofCD17/CD34expressioninALLandAMLpatientswerecompared.Twentyhealthyindividualsweresetascontrols.andtofollow-upvisitedandcomparedthecurativeeffectandprognosisbetweenCD17/CD34CO.expressionAMLpatientsand
6、CD17/CD34no—expressionAMLpatients.RESULTS:Thereisnoexpressioninthehealthyindividuals.111epositiverateofCD17/CD34wasnotdifferentinALLthaninthehealthyindividuals(6.6%VSO%,P>0.05).TheCO.expressionrateofCD17/CD34wassignificantlyhigherinAMLthaninALL(49.2%VS6.6%,P<0.05).TheCO—expressionrateofCD17/CD3
7、4wassignificantlyhigherinAMLthaninthehealthyindividuals,too(49.2%VsO%,P
此文档下载收益归作者所有