《b型肝炎的製藥》PPT课件

《《b型肝炎的製藥》PPT课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、B型肝炎的製藥第一組主講人：生科系江筱筠生科系陳勃睿科管所王聰哲生科系齊康Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Ｂ型肝炎（hepatitisB）病毒性肝炎傳染方式傳染途徑B型肝炎病毒潛伏期約二個月或更久傳染途徑(1)母子傳染（又稱垂直傳染）(2)水平感染Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011Asp

2、osePtyLtd.B型肝炎病毒不完全雙股DNA病毒分類上屬於hepadnavirus大小約為42nm西元1965年Blumberg所發現“澳洲抗原”(1976NobelPrize)Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.B肝病毒Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Hep

3、atitisBVirus(HBV)surfacecoatinnerproteinshell=coreparticle=capsidEvaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.B型肝炎表面抗原(hepatitisBsurfaceantigen)B型肝炎核心抗原(hepatitisBcoreantigen)核心抗原的一部份會被釋放到受感染的細胞外，成為B型肝炎e抗原(hepatitisBeantigen,HBeAg)Evaluationonl

4、y.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Howthevirusreproduces?Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Firstthevirusattachestoalivercell’smembrane.nucleusEvaluationonly.CreatedwithAspose.Slide

5、sfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Thevirusisthentransportedintothelivercell.nucleusEvaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Thecoreparticlethenreleasesit'scontentsofDNAandDNApolymeraseintothelivercellnucleus.nuc

6、leusEvaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Oncewithinthecellnucleus,theHBVDNAcausesthelivercelltoproduce,viamRNA,surfaceproteins,coreprotein,DNApolymerase.DNApolymerasecausesthelivercelltomakecopiesofHBVDNAfrommRNA.DNAEvaluationonly.Creat

7、edwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Thecellthenassemblescopiesofthevirus.Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright200