资源描述：
《荞麦粉对高脂膳食大鼠脂代谢的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、现代食品科技ModernFoodScienceandTechnology2015,Vol.31,No.6荞麦粉对高脂膳食大鼠脂代谢的影响1,21,211,21,2王丹，葛洪娟，张笑，张岚，宋春梅（1.吉林医药学院公共卫生学院，吉林吉林132013）（2.吉林省中医药管理局二级实验室，吉林吉林132013）摘要：本文研究了荞麦粉（buckwheat，BW）对高脂膳食大鼠脂代谢的影响。将50只成年Wistar雄性大鼠随机分为基础对照组、高脂模型组、荞麦粉低、中、高剂量组（1、5、10g/kg·d），每天喂食一次，饲喂30d后腹主动脉取血，取出肝脏、肾周及睾丸附近脂肪，分别
2、测定血清和肝脏中的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平，并观察肝脏病理切片。结果表明，与高脂膳食组相比，荞麦剂量组大鼠体重和食物摄入量都明显减少，肝重和脂肪重及其指数也明显降低，血清和肝脏中TC、TG、LDL-C的浓度降低，HDL-C的浓度升高。肝脏光镜结构表明，荞麦剂量组的肝脏脂肪变性均减轻，其中荞麦粉高剂量作用最为明显。说明荞麦粉干预高脂膳食，可起到降血脂、改善肝脏脂代谢、保护肝脏的作用，同时能够减少相关疾病的发生。关键词：荞麦粉；高脂膳食；脂代谢；光镜结构文章篇号：1673-9078(201
3、5)6-23-28DOI:10.13982/j.mfst.1673-9078.2015.6.005EffectofBuckwheatonLipidMetabolisminHigh-fatDiet-fedRats1,21,211,21,2WANGDan,GEHong-juan,ZHANGXiao,ZHANGLan,SONGChun-mei(1.DepartmentofPublicandHealth,JinlinMedicalcollege,Jilin132013,China)(2.LeverTwoLaboratoryofAdministrationofTradition
4、alChineseMedicineofJilinProvince,JinlinMedicalcollege,Jilin132013,China)Abstract:Theaimofthisstudywastoelucidatetheeffectofbuckwheat(BW)onlipidmetabolisminhigh-fatdiet-fedrats.Fiftymaleratswererandomlydividedintothefollowinggroups:controldiet,high-fatdiet(HFD),low-doseBW(1g/kg·d),medium
5、doseBW(5g/kg·d),andhighdoseBW(10g/kg·d).Theratswerefedonceadayfor30days.Bloodsamplesweresubsequentlycollectedfromtheposteriorabdominalaorta,andtheliver,inaddition,perirenalfat,andepididymalfatwerecollected.Thelevelsoftotalcholesterol(TC),triglycerides(TG),highdensitylipoproteincholester
6、ol(HDL-C),andlowdensitylipoproteincholesterol(LDL-C)intheserumandliverweremeasured,andpathologicalsectionsofthelivertissueswereobserved.TheresultsshowedthatcomparedtotheHFDgroup,theweightandfoodintakeofalltheBWgroupsweresignificantlylower,theweightsandindexesoftheliverandfattissueswerea
7、lsosignificantlyreduced,theconcentrationofTC,TG,andLDL-Cintheserumandliverweredecreased,andtheconcentrationofHDL-Cwasincreased.Meanwhile,theliverstructureobservedunderthelightmicroscopeshowedthathepaticsteatosisinallBWgroupswasalleviated,withthemostsignificanteffectobservedinth
