固冲止血汤治疗气虚血瘀型功血出血期的临床研究

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1、山东中医药大学硕士学位论文固冲止血汤治疗气虚血瘀型功血出血期的临床研究姓名：鹿鸣瑞申请学位级别：硕士专业：中医妇科学指导教师：刘金星2003.4.20提要淞olel-!目的：运用中i『I『医理论，从理论及临床方面对固冲止血汤治疗气虚血瘀型功血出血期的疗效及止血机理进行系统探讨。方法：’将60例气虚血瘀型功血患者随机分为治疗组(30例，[fJj民固冲止血汤)及对照组(30劁，口服益宫止血口服液)观察止血疗效、治疗前后临床症状改善情况、子宫内膜厚度、凝血酶原时间及部分凝血活酶时间、血清Ca2+水、F、内分泌激素、经血

2、血清PGE2及PGF2。、子宫内膜ER、PR含量等的变化。结果：固冲止血汤治疗止血疗效总有效率为93．3％，显著优于对照组(P0．05)；治疗组治疗后在改善临床症状、子宫内膜的厚度、凝血酶原时间及部分凝血活酶肘问、血清ca2+水平、经血血清PGF．2及PGF2。、子宫内膜ER、PR含量等方面，jj疗前相比均有显著性差异(P

3、01)，且治疗组与对照组疗后两组问比披亦有显著性差异(P

4、gWithQiDeficiencyandBloodStasisSyndromeSpeciality：GynecologyofTraditionalChineseMedicineAuthor：LuMingroiTutor：ProfLiuJinxingAbstract0bjective：ToexploresystematicallytheeffectandthehemostasisprincipleofGuchongZhixueDecoction(GCZXD)intreatingdysfunctionaluterin

5、ebleeding(DUB)withQideficiencyandBloodstasissyndromebasedonthetheoreticalandclinicalresearchundertheguidanceoftraditionalandwesternmedicaltheory．Method：60patientsweredividedrandomlyintotestgroup(30cases．treatedwithGczXD)andcontrolgroup(30cases，treatedwithYigo

6、ngZhixueMixtures)．Thehemostasiseffect,theimprovementsofclinicalsymptoresandthedensityofeudometriura,prothrombrntime(PT)andactivatedpartialprothrombrntime(APTT),thesernmlevelofC∥-senJmsexhormone，theconcentrationsofPGE2andPGF2。，thelevelsofendometrialERandPRwere

7、observed．Results：GCZXDcouldimproveclinicalsymptomsofpatientsobviously,andthedifferencewassignificantcomparedtocontrolgroup．Meanwhile,thedensityofendometriumandPT,APTTweredecreased．theserumlevelofca2+wasincreasedcomparedtothatofthepretherapy,andthedifferencewa

8、ssignificantcomparedtocontrolgroup．ItshowedthattheefficiencyoftestgroupissignificantlysuperiortothatofcontrolgroupinadjustingPGE2／PGF2。andER／PR．Conclusion：G-CZXDisaneffectiverecipeintreat