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1、中华实验和临床感染病杂志(电子版)2017年8月第11卷第4期ChinJExpClinInfectDis(ElectronicEdition),August2017,Vol.11,No.4·335··临床论著·女性慢性乙型肝炎患者血清性激素变化特点及影响因素111112李红芳李丽易为白玉青庄虔莹高明龙【摘要】目的探讨女性慢性乙型肝炎患者血清性激素的变化特点及影响。方法收集本院收治的慢性乙型肝炎患者（肝炎组）和健康女性（对照组）各30例，采用微粒子化学发光法测定其血清中促卵泡生成素（FSH）、黄体生成素（LH）、
2、雌二醇（E2）、孕酮（P）、睾酮（T）和催乳素（PRL），对两组的性激素水平和绝经比例进行比较。结果与对照组相比，肝炎组患者血清中FSH和T水平显著升高，差异均具有统计学意义（t=－2.119、P=0.038，t=－2.312、P=0.024）；肝炎组患者E2水平显著降低，差异具有统计学意义（t=2.542、P=0.014）；两组患者血清中LH、PRL和P2水平差异均无统计学意义（P均＞0.05）。肝炎组患者的绝经比例显著高于对照组（χ=4.3886、P=0.0362）。结论慢性乙型肝炎可致女性患者血清中FSH
3、和T升高、E2降低、绝经提前。【关键词】女性；肝炎，乙型，慢性；性激素Characteristicsandinfluencingfactorsofserumsexhormonesinfemalepatientswithchronichepatitis1111121BLiHongfang,LiLi,YiWei,BaiYuqingZhuangQianying,GAOMinglong.DepartmentofObstetrics2andGynecology,BeijingDitanHospital,CapitalMe
4、dicalUniversity,Beijing100015,China;DepartmentofAnesthesiology,PLAArmyGeneralHospital,Beijing100700,ChinaCorrespondingauthor:GaoMinglong,Email:gaominglongg@163.com【Abstract】ObjectiveToinvestigatecharacteristicsandinfluencingfactorsofserumsexhormonesinfemalep
5、atientswithchronichepatitisB.MethodsChronichepatitisBpatients(hepatitisgroup)andhealthywomen(controlgroup)with30caseswerecollectedinourhospital.Folliclestimulatinghormone(FSH),luteinizinghormone(LH),estradiol(E2),andprogesterone(P),testosterone(T)andprolacti
6、n(PRL)inserumweremeasuredbychemiluminescentimmunoassay,andthelevelsofsexhormonesandproportionofmenopausewerecomparedbetweenthetwogroups.ResultsComparedwiththegroupC,thelevelsofFSHandTinpatientsofCHBgroupweresignificantlyincreased,withsignificantdifferences(t
7、=－2.119,P=0.038;t=－2.312,P=0.024),andE2inpatientsofCHBgroupdecreasedsignificantly,withsignificantdifference(t=2.54,P=0.014).ThelevelsofLH,PandPRLinpatientsofthetwogroupwerewithoutsignificantdifferences(allP>0.05).TheproportionofmenopauseofpatientsinCHBgroupw
8、assignificantlyhigher2thanthatofthecontrolgroup(χ=4.3886,P=0.0362).ConclusionChronichepatitisBaoleadtheincreaseoflevelsofFSHandTintheserumoffemalepatients,andthedecreaseofE2,andearlymenopause.【K
