食管癌组织中Survivin和Ki67的表达及临床意义

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1、食管癌组织中Survivin和Ki67的表达及临床意义作者：李秀娟范婕李玉珍王淑强【摘要】目的：观察Survivin和Ki67在食管鳞癌中的表达，并探讨Survivin与Ki67的表达关系及其临床意义。方法：应用免疫组织化学法检测70例食管鳞癌组织石蜡切片Survivin和Ki67的表达，分析Survivin表达与临床病理因素及Ki67的关系。结果：Survivin在食管鳞癌组织中的表达率为72.9%(51/70)，Ki67在食管鳞癌组织中的表达率为67.1%(47/70)。Survivin表达和Ki67表达与食管鳞癌分化程度、淋巴结转移、TNM分期明显相关(P<0

2、.05)。Survivin表达和Ki67表达呈正相关(P<0.05)。结论：Survivin和Ki67可作为判断食管癌组织恶性程度和预后的指标之一。【关键词】食管;鳞状细胞/肿瘤;Survivin;Ki67EsophagealcarcinomaisoneofthemostfrequentlymalignanttumorsinChina.Amethodforidentifyingcancercellproliferationandspreadingisimportanttocommencetheeffectivetreatmentandtoimprovesurviva

3、lforESCCpatients.Theprocessofesophagealtumorigenesisatthemolecularlevelisrelatedtodisordersofcell12amplification,differentiation,senescenceandapoptosis.Thegeneticbasesunderlyingesophagealtumorigenesishavebeenpartlyunderstoodinthepastfewyears,includingalossoftheantioncogenep53andoverexpr

4、essionofepidermalgrowthfactorreceptororcMyc[1].However,othermolecularmechanismsinvolvedinesophagealtumorigenesisprogressarestillwidelyunknown.　　Survivinisakindofproteinthatishighlyexpressedinavastnumberofmalignancies,butisminimallyexpressedinnormaltissues.Itplaysaroleasaninhibitorofcelld

5、eathincancercells,thusfacilitatingthegrowthofthesecells[2].Ki67isamarkerofcellgrowth.Thismuclearantigenisexpressedduringallphasesofthecellcycle(G1,S,G2andmitosis),exceptphaseG0.Inrecentstudies,importantcorrelationwasfoundbetweenki67andthegrowth,invision,metastasisandprognosis[3].Inthisstu

6、dy,theeffectsofSurvivinandKi67intheformationandprogressionofESCCwereinvestigated,andtheexpressionoftheminESCCwasdetected.　1MATERIALSANDMETHODS12　　1.1ClinicalData　　70caseswithESCCwereselectedfromtheFirstAffiliatedHospitalofHebeiNorthUniversityfromJanuary2000toJune2005.Therewere23maleand47f

7、emale.Thepatientsweregivenpreoperativeexaminationincludingbiopsyfordiagnosis,bariumXrayandCT,andnotreatmentwasgivenbeforeoperation.Radicalresectionwasperformedineachpatient,andallthesamplesunderwentpostoperativepathologicalexamination.Therewere40caseswithstageⅠ～Ⅱan