ERK1_2在子宫内膜癌中的表达以及与雌、孕激素受体相关性

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1、上海交通大学硕士学位论文ERK1/2在子宫内膜癌中的表达以及与雌、孕激素受体相关性姓名：鲍伟申请学位级别：硕士专业：妇产科学指导教师：万小平;席晓薇20080501清CA125水平及五年生存率密切相关(P＜0.05)。3.ERK1/2的表达与ER、PR的相关性:○1p-ERK1/2在ER阳性子宫内膜癌与ER阴性子宫内膜癌中的表达有显著性差异(P＜0.05)，p-ERK1/2在子宫内膜癌中的表达与ER的表达水平呈正相关(r=0.457)。○2p-ERK1/2、ER和PR的表达与子宫内膜癌患者术后生存时间无明显相关性(P＞0.05)。结论：ERK1/2信号转导通路与

2、子宫内膜恶变过程无相关性；它的活化与ER表达水平呈正相关。肿瘤细胞分化程度越高，ER、PR的表达水平越高，且PR的表达与肿瘤的腹水转移呈反相关。ER可能通过ERK1/2信号通路发挥其在子宫内膜癌中的调控作用。关键词：子宫内膜癌，细胞外信号调控激酶1/2，雌激素受体，孕激素受体EXPRESSIONOFERK1/2ANDITSRELATIONTOER,PRINENDOMETRIALCARCINOMAABSTRACTObjective:Todetecttheexpressionofextracellularsignal-regulatedkinase1/2(ERK1/

3、2)innormal,hyperplastic,andmalignantendometrium,andinvestigatetheexpressionandactivationofERK1/2withrelationtotheexpressionofERandPRinendometrialcarcinoma.Methods:TheexpressionoftotalandphosphorylatedERK1/2from20normalendometria,13hyperplasticendometriaand30endometrialcarcinomaswered

4、etectedwithimmunohistochemistrymethod.TheexpressionofERandPRin30endometrialcarcinomawerealsodetected2withthesamemethod.Thedatawereanalyzedwith?testorFisher’sexacttest,Spearmantest,Life-tableandKaplan-Meiercurve.Results:1.ExpressionofERK1/2:(1)Therearenosignificantdifferenceintheexpre

5、ssionoft-ERK1/2、p-ERK1/2amongnormal,hyperplastic,andmalignantendometria(P＞0.05).(2)Theexpressionratesoft-ERK1/2、p-ERK1/2havenorelationshipwithclinicinformation,clinicopathologicalandprognosticcharactersinendometrialcancer(P＞0.05).2.ExpressionofERandPRinendometrialcarcinoma:(1)Theexpr

6、essionratesofERandPRweresignificantlyrelatedwithhistologicalgrade(P＜0.05),butnotrelatedwithotherclinicopathologicalcharacters(FIGOstage,myometrialinvasiondepthandlymphnodesmetastases,P＞0.05).(2)TheexpressionofPRwaslowerinascitesmetastasisgroup(P＜0.05).(3)ExpressionofERhascloserelatio

7、nshipwithpatient’sCA125valueandfiveyearsurvivalrate(P＜0.05).3.RelationshipofERK1/2expressionandER,PRexpressioninendometrialcarcinoma:(1)p-ERK1/2arehigherexpressedinERpositiveendometrialcarcinomathaninERnegativeones(P＜0.05).(2)ExpressionofER,PRandp-ERK1/2havenorelationshipwithpatient’

8、slivetime(P＞