HIVAIDS患者外周血可溶性白介素2受体变化的临床研究

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1、兰州医学院硕士学位论文HIV/AIDS患者外周血可溶性白介素2受体变化的临床研究姓名：冯鲜妮申请学位级别：硕士专业：内科学（传染病）指导教师：郭长劳;吴昊2002.6.1兰州I医学院硕上研究’}毕业论文ABSTRACTObjective：TheserumsolubleIL一2receptor(SIL一2R)levelswereobservedinnormalhealthycontrols，H1V／A1DSpatients，patientswithhepatitisCandH1V／AIDSpatientscomplicatedwithhepatitisCObserveth

2、einfluenceofCD41，CDs+Tcellcounts，plasmaviralload，clinicalmanifestationandcomplicationsonserumSIL一2RlevelsS1L一2RdeterminationjnevaluationprognosisandeffectassessmentToexploretheclinicalsignificanceofdiseasecondition，progression，Methods：137casesofHIV／A1DSpatientswerechosen，wedeterminatedth

3、eirperipheralbloodCD4+，CDs+andCD4+CD25。’TcellcountsbyflowcytomenY．detectedtheserumSIL一2RlevelswithELISA，detectedtheplasmaviralloadln57patientswithb-DNAWealsodeterminatedserumSIL-2Rlevelsin20healthyblooddonorsand36patientswithhepatitisCwithELISAResults：1HigherlevelsofS1L一2Rwerefoundinthes

4、eraofHIV／A1DSpatients，HCVpatientsandHIV／A1DSpatientscomplicatedwithhepatitisC(2825±1143pg／mland22864-1065pg／m1)BothSIL一2Rlevelswerehigherthanthoseofnormalcontrols(12494-447pg／m1)2TheserumS1L一2RlevelsofAIDSpatientswashigherthanthoseofasymptomaticindiVidualsf3053±916pg／mIversus21874-1045pg

5、／m1)ButCD44TcellcountsofasymptomaticpatientswerehigherthanthoseofAIDSpatients(87±6l／mm3versus3444-120／mm3)TherewasnegativecorrelationbetweenSIL一2RlevelsandCD4+Tcellcounts(F—O656，P<0001)4兰州医学院硕士研究生毕业论文3Amongnormalhealthycontrols，HCVpatients，HIV—seropositiveindividualsandHIV—seropositivepa

6、tientscomplicatedwithhepatitisC，theserumSIL一2RlevelsofHIV—seropositiveindividualscomplicatedwithhepatitisCwerethehighest(3132pg／m1)，andHIV—seropositivegroupwashigherthanHCVgroup，buttherewasnodifferencestatisticsly4AmongHIVinfectionpatients，theS1L一2Rlevelsofthepatientscomplicatedwithoppor

7、tunisticinfectionwerehigherthanthoseofthepatientswithoutopportunisticinfection(3343±839pg／mlversus2570±10l6pg／m1)Asignificantdifferenceexitedintwogroups5TherewerenegativecorrelationbetweenS1L一2RlevelsandCD4+Tcellcounts，CD8+Tcellcounts；butpositivecorrelationbetweenB2一Mleve