Lipidmetabolism脂类代谢

Lipidmetabolism脂类代谢

ID:36411329

大小:1.30 MB

页数:37页

时间:2019-05-09

Lipidmetabolism脂类代谢_第1页
Lipidmetabolism脂类代谢_第2页
Lipidmetabolism脂类代谢_第3页
Lipidmetabolism脂类代谢_第4页
Lipidmetabolism脂类代谢_第5页
资源描述:

《Lipidmetabolism脂类代谢》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库

1、10.LipidmetabolismHuangxiaoLinyiuniversityKeynotesStructuresandrolesoffattyacidsFattyacidbreakdownFattyacidsynthesisTriacylglycerols10.1StructuresandrolesoffattyacidsFattyacidshavealonghydrocarbonchainwithaterminalcarboxylicacidgroup.Mostfattyacidshaveanevennum

2、berofcarbonatomsinanunbranchedchain.Saturatedfattyacidshavenodoublebondsbetweenthecarbonatoms,whereasmono-andpolyunsaturatedfattyacidshaveoneormoredoublebonds.Stearicacid(b)Fattyacidshavefourmajorbiologicalroles:1)Theyarecomponentsofmembranes(glycerophospholipi

3、dsandsphingolipids)2)Severalproteinsarecovalentlymodifiedbyfattyacids.3)Theyactasenergystores(triacylglycerols)andfuelmolecules.4)Fattyacidderivativesserveashormonesandintracellularsecondmessengers.10.2FattyacidbreakdownOverviewActivationTransportintomitochondr

4、iaβ-oxidationpathwayEnergyyieldKetonebodies1.overviewFattyacidbreakdownbringsabouttheoxidationoflong-chainfattyacids.ThefattyacidsarefirstconvertedtotheiracylcoenzymeAderivativesandthendegradedbythesuccessiveremovaloftwo-carbonunitsfromtheendofthefattyacidasace

5、tylCoA.IncytosolAcylCoAsynthetase2.FattyacidactivationRCOOH+CoA—SHRCO~SCoAAcylCoAsynthetaseATPAMP+PPiMg2+H2O2PithereactionisirreversiblefattyacidacylCoA3.TransportintomitochondrialongerchainacylCoAsdonotreadilycrosstheinnermitochondrialmembrane,andrequireaspeci

6、fictransportmechanism.RCO-SCoACoA-SHtransferase(CH3)3N+-CH2CH-CH2COOHOHcarnitine(CH3)3N+CH2CHCH2COOHRCO-OacylcarnitineR-COSCoAH-SCoAcarnitineR-CO-carnitineR-CO-carnitineH-SCoAcarnitineR-COSCoAtransferaseⅠβ-oxidationtransferaseⅡInnermitochondrialmembrane4.β-Oxid

7、ationpathwayOxidation(byFAD)HydrationOxidation(byNAD+)Thiolysis①oxidationacylCoAdehydrogenaseFADFADH2②hydrationRCH2CCCO~CoAHHtrans2-enoylCoAenoylCoAhydrataseH2OOHRCH2CHCH2CO~SCoA3-hydroxyacylCoA1.5ATPrespiratorychainOR-CH2-CH2C-SCoA

8、

9、OHRCH2CHCH2CO~SCoA③oxidati

10、onNAD+NADH+H+dehydrogenase④thiolysisCH3CO~SCoARCH2CO~SCoA(1)(2)(3)(4)3-ketoacylCoARCH2C~SCoAOCH2COCoA-SHketothiolase2.5ATPrespiratorychainroundreactionOxidationofodd-chainfa

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。