stem cells - winston-salemforsyth county schools：干细胞-温斯顿salemforsyth县学校

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1、StemCellsRemarkableRegeneration!Canhumansregeneratebodyparts?Canhumansregeneratebodyparts?Think–Pair–ShareIfhumanshavestemcellsbutcan’tgrowbackcertainbodyparts,butalizardcangrowbackanentiretail,whatmustbedifferentbetweenourstemcellsandalizard’s?Somestemcellsaredifferentthanothers!Stemcellsvary

2、inwhattheycanbecome.Somestemcellscanonlybecomeonetypeofcell,otherstemcellscangenerateanentireorganism!StemCellsPotencyTotipotentPluripotentMultipotentUnipotentStemCellsPotencyTotipotentPluripotentMultipotentUnipotentStemCellsPotencyTotipotent:astemcellthathastheabilitytodivideandproduceallthed

3、ifferentiatedcellsinanorganism,includingtheplacenta.AtotipotentstemcellcangenerateanENTIREorganism!Example:cellfrommorulastageofembryoStemCellsPotencyTotipotentPluripotentMultipotentUnipotentStemCellsPotencyPluripotent:astemcellthathastheabilitytodivideanddifferentiateintoanyfetaloradultcellty

4、pe(butnottheplacenta).Thus,apluripotentstemcellcandifferentiateintoanycelltypebutcannotbecomeaneworganism.Example:cellfrominnercellmassofblastocystStemCellsPotencyTotipotentPluripotentMultipotentUnipotentStemCellsPotencyMultipotent:astemcellthathastheabilitytodivideanddifferentiateintocellsofa

5、limitedrangeoftypes.Example:Bloodstemcell(hematopoieticcell)StemCellsPotencyTotipotentPluripotentMultipotentUnipotentStemCellsPotencyUnipotent:astemcellthathastheabilitytodivideanddifferentiateintoonlyonetypeofcell.Example:SkinstemcellsStemCellsSo,whatISastemcell?StemCellsStemCellsThink–Pair–S

6、hareThinkbacktothedefinitionsofpotencywejustdiscussed.Whattwocharacteristicsdoallstemcellshaveincommon?So,whatISastemcell?Twodefiningcharacteristics…Self-renewal:Retainthecapacitytogothroughmanycyclesofcelldivisionwhileremainingundifferentiated.Potency:AbilitytodifferentiateStemCellsSo,whatISa

7、stemcell?Astemcellisacellthathastheabilitytoself-renewanddifferentiatealongdifferentpathways.StemCellsEmbryonicstemcellsvs.AdultStemcellsEmbryonicstemcell:stemcellderivedfromtheinnercellmassofanembryo.ArepluripotentEmbryonicstemcellsvs.