阿司匹林和acei相互作用

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1、今天读了Stocklcy，sDrugInteractions8thEdition,其中阿司匹林与ACEI的相互作用有详细的说明,供大家参考：Theanlihypertensiveefficacyofcaptopri1andenalapri1maybereducedbyhigh-doseaspirininabout50%ofpatier)ts.Low-doseaspirin(lessthanorequalto100mgdaily)appearstohavelittleeffect・Itisunclearwhetheraspirinattenuatesthebenefitso

2、fACEinhibitorsinheartfailure・Thelikelihoodofaninteractionmaydependondiseasestateanditsseverity.Renalfailurehasbeenreportedinapatienttakingcaptoprilandaspirin・ClinicalevidcnccA.Effectsonbloodpressure(a)CaptoprilAspirin600mgevery6hoursfor5dosesdidnotsignificantlyalterthebloodpressurerespons

3、etoasingle25to100-mgdoseofcaptoprilin8patientswithessentialhypertension・However,thestaglandinresponsetocaptopri1wasblockedin4ofthe8,andinthesepatients,thebloodpressureresponsetocaptoprilwasblunted.1Inanotherstudy,aspirin75mgdailydidnotaltertheantihypertensiveeffectsofcaptopril25mgtwicedai

4、lyin15patientswithhypertension・(b)Enalapri1Twogroupsof26patients,onewithmildtomoderatehypertensiontakingenalapril20mgtwicedailyandtheotherwithsevereprimaryhypertensiontakingenalapriI20mgtwicedaily(withnifcdipinc30mgandatenolol50mgdaily),weregiventestdosesofaspirin100and300rngdailyfor5days

5、・The100-mgdoseofaspirindidnotaltertheefficacyoftheantihypertensivedrugs,butthe300-mgdosereducedtheantihypertensiveefficacyinabouthalfthepatientsinbothgroups・Inthesepatients,theantihypertensiveeffectswerediminishedby63%inthosewithmildtomoderatehypertensionandby91%inthosewithseverehypertens

6、ion・Incontrast,anotherstudyin7patientswithhypertensiontakingenalapri1(meandailydose12・9mg)foundthataspirin81mgor325mgdailyfor2weeksdidnothaveanysignificanteffectonbloodpressuro.4Afurtherstudyin18patientsalsofoundthataspirin100mgdailyfor2weeksdidnotaltertheantihypertensiveeffectofenalapril

7、20or40mgdaily.(c)UnspccifiedACEinhibitorsInarandoinisedstudy,theuseoflow-doseaspirin100mgdailyfor3monthsdidnotalterbloodpressurecontrolinpatientstakingcalciumchannelblockersorACEinhibitors,whencomparedwithplacebo.Similarly,inarc-analysisofdatafromtheHypertensionOpti