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ID:35498499
大小:57.95 KB
页数:4页
时间:2019-03-25
《阿司匹林和acei相互作用》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、今天读了Stocklcy,sDrugInteractions8thEdition,其中阿司匹林与ACEI的相互作用有详细的说明,供大家参考:Theanlihypertensiveefficacyofcaptopri1andenalapri1maybereducedbyhigh-doseaspirininabout50%ofpatier)ts.Low-doseaspirin(lessthanorequalto100mgdaily)appearstohavelittleeffect・Itisunclearwhetheraspirinattenuatesthebenefitso
2、fACEinhibitorsinheartfailure・Thelikelihoodofaninteractionmaydependondiseasestateanditsseverity.Renalfailurehasbeenreportedinapatienttakingcaptoprilandaspirin・ClinicalevidcnccA.Effectsonbloodpressure(a)CaptoprilAspirin600mgevery6hoursfor5dosesdidnotsignificantlyalterthebloodpressurerespons
3、etoasingle25to100-mgdoseofcaptoprilin8patientswithessentialhypertension・However,thestaglandinresponsetocaptopri1wasblockedin4ofthe8,andinthesepatients,thebloodpressureresponsetocaptoprilwasblunted.1Inanotherstudy,aspirin75mgdailydidnotaltertheantihypertensiveeffectsofcaptopril25mgtwicedai
4、lyin15patientswithhypertension・(b)Enalapri1Twogroupsof26patients,onewithmildtomoderatehypertensiontakingenalapril20mgtwicedailyandtheotherwithsevereprimaryhypertensiontakingenalapriI20mgtwicedaily(withnifcdipinc30mgandatenolol50mgdaily),weregiventestdosesofaspirin100and300rngdailyfor5days
5、・The100-mgdoseofaspirindidnotaltertheefficacyoftheantihypertensivedrugs,butthe300-mgdosereducedtheantihypertensiveefficacyinabouthalfthepatientsinbothgroups・Inthesepatients,theantihypertensiveeffectswerediminishedby63%inthosewithmildtomoderatehypertensionandby91%inthosewithseverehypertens
6、ion・Incontrast,anotherstudyin7patientswithhypertensiontakingenalapri1(meandailydose12・9mg)foundthataspirin81mgor325mgdailyfor2weeksdidnothaveanysignificanteffectonbloodpressuro.4Afurtherstudyin18patientsalsofoundthataspirin100mgdailyfor2weeksdidnotaltertheantihypertensiveeffectofenalapril
7、20or40mgdaily.(c)UnspccifiedACEinhibitorsInarandoinisedstudy,theuseoflow-doseaspirin100mgdailyfor3monthsdidnotalterbloodpressurecontrolinpatientstakingcalciumchannelblockersorACEinhibitors,whencomparedwithplacebo.Similarly,inarc-analysisofdatafromtheHypertensionOpti
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