牛磺酸对丙二醛诱导疲劳大鼠的保护作用

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1、牛磺酸对丙二醛诱导疲劳大鼠的保护作用牛磺酸对丙二醛诱导疲劳大鼠的保护作用摘要：目的：研究丙二醛（MDA）诱导的运动性疲劳及牛磺酸（Tau）抗运动性疲劳作用及可能的机制。方法：60只SD大鼠分成对照组（C组）、生理盐水组（E组）、Tau组（T组）、MDA组（M组）及Tau喂食后再喂食MDA组（T+M组）和MDA喂食后再喂食Tau组（M+T组），测试各组大鼠7d游泳力竭所经历时间变化，及LA和LDH活性，心肌和腓肠肌Ca❷2+❷-ATPase、Na+-K+-ATPase活性的差异。结果：M组大鼠力竭时间缩短而T组大鼠力竭时间延长，T+M组大鼠

2、力竭时间缩短而M+T组大鼠力竭时间又延长；T组大鼠LA降低而LDH活性升高，喂食MDA后则逆转了这一过程，M组大鼠LA升高而LDH活性降低，喂食Tau后也能拮抗这一过程；M组倫❷2+❷-ATPase>Na+-K+-ATPase活性活性降低而T组活性升高，M组大鼠喂食Tmi及T组大鼠喂食MDA后可以逆转这一过程。结论：MDA可以直接诱导运动性疲劳而Tau能有效的抗MDA所诱导的疲劳过程。关键词：牛磺酸，丙二醛，游泳力竭运动，运动性疲劳中图分类号：G804.87文献标识码：A文章编号：1007-3612（2011）03-0071-04TheP

3、rotectionofTaurineforRatsofMaiondialdehydeInducedExerciseFatigueYANGAihual,SHENWeihua2,TANGHua3,CAIJianguang2（1.DepartmentofP・E,ChangshaUniversityofScience&Technology,Changsha,410001,HunanChins;2.DepartmentofP・E.,HunanUniversityofScience&Technology,Xiangtan410200,HunanChi

4、na;3.HunanCityUniversity,DepartmentofP.E.,Yiyang410300,HunanChina）Abstract:Objective:Toinvestigatemalondialdehyde(MDA)inducedexercisefatigueandtheprotectionoftaurine(Tau)forrats.Methods:60ratsweredividedintocontrolgroup(Cgroup),physiologicalsalinegroup(Egroup),taurinefedg

5、roup(Tgroup),MDAfedgroup(Mgroup)forsevendays,respectively.ThenTgroupfedwithMDA(T+Mgroup),andMgroupfedwithtau(M+Tgroup)forsevendays,respectively.Thedurationofswimmingexhaustiveexercisewasrecordedofallgroupsofratsinthesevendays,andalsothelevelsoflacticacid(LA),thereactivity

6、oflacticdehydrogenase(LDH)weredetermined,andthenthereactivityofCa❷2+❷ATPase,Na.+K+ATPasefromcardiacmuscleandgastrocnemiusweredetectedbyspectrophotometer・Results:ThedurationofswimmingexhaustiveexercisewasshortenedfortheMgroupandwasprolongedfortheTgroupinthefirstsevendaystr

7、eatment,anditwasthenreducedfortheT+Mgroup,increasedfortheM+Tgroupinthenextsevendaystreatment・ThelevelsofLAweredecreasedandthereactivityofLDIIwasincreasedintheTgroup,theMgroupwasreversetotheTgroupinthefirstsevendaystreatment・ThelevelsofLAwerethenincreasedandthereactivityof

8、LDIIweredecreasedintheT+MgroupandtheM+TgroupratswerereversetotheT+Mgroupinthenextsevendaystreatm