不同剂量瑞舒伐他汀治疗对急性冠脉综合征患者pci术后ptx3、nt-probnp浓度的影响

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1、授予单位代码10089学号或申请号12257HebeiMedicalUniversity硕士学位论文在职科学学位不同剂量瑞舒伐他汀治疗对急性冠脉综合征患者PCI术后PTX3�NT-proBNP浓度的影响学位申请人：杨怡导师：张军教授专业：内科学二级学院：沧州市中心医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组〉的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第

2、一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名导师签章河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。如/上年尸月"曰目录中文摘要·············································································

3、·1英文摘要··············································································4研究论文不同剂量瑞舒伐他汀治疗对急性冠脉综合征患者PCI术后PTX3、NT-proBNP浓度的影响前言··············································································7材料与方法···············································

4、······················8结果·············································································13附表·············································································15讨论·············································································22结

5、论·············································································27参考文献·······································································29综述他汀类药物对防治心血管疾病的非调脂作用的研究进展··········33致谢······································································

6、·············45个人简历·············································································46中文摘要不同剂量瑞舒伐他汀治疗对急性冠脉综合征患者PCI术后PTX3、NT-proBNP浓度的影响摘要目的：本研究通过比较不同剂量的瑞舒伐他汀（Rosuvastatin,Rosu）对择期行经皮冠状动脉成形术（percutaneouscoronaryintervention,PCI）的急性冠脉综合征（acutecoronarysyndro

7、me，ACS)患者治疗疗效，探讨瑞舒伐他汀减少ACS患者围PCI期心肌损伤发生情况的机制及术后30天的临床疗效，为择期行PCI术ACS患者应用他汀类药物提供客观依据。方法：本研究入选60例ACS并择期行PCI术患者，依据随机数字表法随机分为3组。瑞舒伐他汀低剂量治疗组（20例，5mg/qn，至少口服1月）；瑞舒伐他汀常规剂量治疗组（20例，10mg/qn，至少口服1月）；瑞舒伐他汀强化剂量治疗组（20例，20mg/qn，至少口服1月）。所有入选患者入院后详细记录临床资料，包括姓名、性别、年龄、高血压史、糖尿病史、个人吸烟史、家族

8、史、三大常规、血糖、血脂（总胆固醇TC、甘油三酯TG、低密度脂蛋白LDL-C、高密度脂蛋白HLD-C）、肝功能、肾功能、CK-MB、hs-cTnI、NT-proBNP、PTX3、处理血管数量等相关数据。观察指标：（1）三组患者PCI术前、术后24hCK-MB（c