动脉自旋标记技术在paod患者小腿肌灌注方面的可重复性测量

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1、授予单位代码10089学号或申请号20122235HebeiMedicalUniversity硕士学位论文科学学位动脉自旋标记技术在PAOD患者小腿肌灌注方面的可重复性测量研究生：张文强导师：崔建岭教授专业：影像医学与核医学二级学院：第三医院2015年3月河北医科大学竿位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署j为单位河北医科大学，试验材料

2、、原始数据、申报的专利等知识权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签章二级学院领导盖章i年i月幹曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果；指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名导师签章：目录中文摘要·············································································1英文摘要·

3、············································································3英文缩写·············································································5研究论文动脉自旋标记技术在PAOD患者小腿肌灌注方面的可重复性测量前言·············································································

4、6材料与方法····································································8结果·············································································9附图·············································································13附表·································

5、············································14讨论·············································································15结论·············································································19参考文献···························································

6、············19综述动脉自旋标记灌注技术的研究新进展································23致谢···················································································34个人简历·············································································35中文摘要动脉自旋标记技术在PAOD患者小腿肌灌注方面的可重复性测量摘要

7、目的：这项研究假设动脉自旋标记核磁共振成像技术在3.0T扫描仪上测量健康志愿者和周围血管病患者小腿肌结扎前后血流灌注方面将是一种可靠无创的技术，并且将对这两个组群进行区分。以往的研究工作证实了钆对比剂的首过效应在周围血管病患者小腿肌灌注测量的实用性。然而，患有周围血管病的患者通常会有进展性的肾疾病，所以不能接受钆对比剂。应用动脉自旋标记测量小腿肌灌注的一大优势就是不用钆对比剂。方法：周围血管病患者的特征有跛行，踝肱指数0.4-0.9。正常对照组年龄要匹配，并且没有周围血管病的任何风险因素。收集周围血管病患者15名，健康对照者30名。所有

8、受试者都采取仰卧位,并以套袖止血带进行结扎以达到缺血后反应性充血，在3.0T扫描仪上对受试者进行扫描。扫描后获得61幅ASL原始图像，通过运动矫正后再进行信号平均得到动脉自旋标记血流量图。灌注峰值是在ASL