生物钟紊乱及吸烟致动脉粥样硬化机制的研究

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1、授予单位代码10089_学号或申请号20120041HebeiMedicalUniversity临床医学博士学位论文生物钟紊乱及吸烟致动脉粥样硬化机制的研究作者姓名：殷洪山导师：李拥军专业：临床医学二级学院：第二医院2015年4月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权归河北医科大学所有。否则，承担相应的法

2、律责任。研究生签名导师2二级学院签章：>丨y年纟月；曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包括其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名:导师签章年〈月2曰目录中文摘要·············································································1英文摘要······················································

3、·······················7英文缩写·············································································15研究论文生物钟紊乱及吸烟致动脉粥样硬化机制的研究引言·············································································17第一部分骨骼肌内在生物钟Bmal1缺乏对肌肉本身代谢的影响前言·················································

4、····························20材料与方法····································································21结果·············································································29附图·············································································32附表·······················

5、······················································38讨论·············································································39小结·············································································45参考文献······································································

6、·46第二部分骨骼肌内在生物钟Bmal1缺乏对全身代谢的影响前言·············································································51材料与方法····································································51结果·············································································54附图·······················

7、······················································56讨论·············································································60小结·············································································62参考文献··························