胱抑素c在窒息新生儿肾功能损害中的诊断价值

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1、授予单位代码学号或申请号13228-MxvHebeiMedicalUniversity硕士学位论文在职科学学位胱抑素c在窒息新生儿肾功能损害中的诊断价值学位申请人：刘军霞导师：李月梅教授专业：儿科学二级学院.•第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下,由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医

2、科大学所有。否则,承担相应法律责任。：>研究生签名；

3、··························································3研究论文胱抑素C在窒息新生儿肾功能损害中的诊断价值前言·············································································5材料与方法····································································6结果········································

4、·····································8附图·············································································10附表·············································································13讨论·············································································1

5、5结论·············································································18参考文献·······································································19综述窒息新生儿肾功能评估的临床研究·····································22致谢·······························································

6、····················32个人简历·············································································33中文摘要胱抑素C在窒息新生儿肾功能损害中的诊断价值摘要目的：通过检测窒息新生儿与正常新生儿中血清胱抑素C（CysC）的水平，探讨CysC在窒息新生儿的变化，分析肾功能损害时各指标间的相关性，评价CysC对窒息新生儿肾功能损害的早期诊断、判断病情、分析预后的实用价值，以期为早期诊断和早期治疗窒息新生儿肾功能损害提供理论依据。方法：按照第四版《实用新生

7、儿学》新生儿窒息诊断和分度标准将窒息新生儿分为轻度窒息组（50例）、重度窒息组（50例）；同期选择20例健康足月新生儿作为对照组。窒息组患儿分别在出生后后第1、3、7天，对照组患儿于生后2～3天通过采取外周静脉血2ml,用酶联免疫吸附法(ELISA)检测血清胱抑素C（CystatinC，SCysC）、血肌酐（serumcreatinine,SCr）、血尿素氮（bloodureanitrogen,BUN）以及血β2-微球蛋白水平（β2-MG），并按Schwartz公式计算估计的肾小球滤过率（estimateglomerularfiltrationrate,

8、eGFR），比较各组间不同时间上述指标的变化，以eGFR作为肾功能损害的评价标准