盐酸鲁拉西酮的合成研究

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1、授予单位代码１＾８＾学号或１２＾申请号＾？巧沁＆钟Ａ多ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位盐酸鲁拉西觀的合成研巧■学位申请人；白雪导师；杜玉民教授Ｗ专业：药物化学二级学院；药学晓２０１５年１０月巧北医科大学学位论文使用授权及知巧产权归属承货本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河化医科大学有权对本学位论文迸行交流、公开和使用。凡发表与学位论文主要内容相关的论文一，第署名为单位河北医科大学，

2、试验材料、申报的专利等知识产权均归河北医科大学所、原始数据有。否则，承担相应法律责任。研究生签名：巧嗦－导师签章：：心＾氏觀戶曰巧化医科大学研究生学位论义独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加标注和致谢等内容夕ｈ，文中不包含其他人已经发表或撰写的研究成果。＊指导教师对此进行了审定本论文由本人独立撰写。，文责自负！研究生签名；向＾导师签章：扶Ｊ—八。年Ｕ月Ｍ日目录中文摘要································································

3、··············1英文摘要··············································································4研究论文盐酸鲁拉西酮的合成研究前言··············································································8材料与方法·····································································8结果·························

4、·····················································12附图··············································································17附表··············································································22讨论···········································································

5、···28结论··············································································29参考文献········································································29综述盐酸鲁拉西酮的研究进展·················································30致谢·································································

6、···················38个人简历··············································································39中文摘要盐酸鲁拉西酮的合成研究摘要精神分裂症（Schizophrenia）是一种常见的精神疾病，据世卫组织估计，全球精神分裂症的终身患病率大概为3.8～8.4‰，美国研究显示该病终生患病率达13‰，据2002年我国卫生部的通报，我国精神分裂症患病率达6.2‰，该病病因复杂，到目前为止仍未完全阐明其原因。经调查青壮年多患此病，通常表现为思维、情感、感知、意志行为等多方面的障碍，精神

7、活动与内心体验和周围环境不协调，脱离现实。一般存在无意识障碍和明显的智能障碍，可有注意、工作记忆、抽象思维和信息整合等方面认知功能损害，病程多迁延，反复发作，部分患者发生精神活动衰退和不同程度社会功能缺损[1-2]。药物治疗仍然是目前首选的治疗措施，盐酸鲁拉西酮与安慰剂相比，对于精神分裂症患者有明显疗效。盐酸鲁拉西酮在治疗精神分裂症方面不存在性别、年龄、人种的差异，且治疗效果显著。而对于双相情感障碍，盐酸鲁拉西酮组单药治疗时，与安慰剂相比具有显