子宫内膜癌患者外周血循环内皮细胞的检测及其临床意义

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1、授予单位代码10089学号或申请号20122365HebeiMedicalUniversity硕士学位论文科学学位子宫内膜癌患者外周血循环内皮细胞的检测及其临床意义研究生：王兴霞导师：李利教授专业：妇产科学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学

2、所有。否则，承担相应法律责任。<1^研究生签名：土長t导师签章：20,体孓月P日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要·············································································1英文摘要···············································

3、······························5英文缩写·············································································10研究论文子宫内膜癌患者外周血循环内皮细胞的检测及其临床意义前言·············································································11材料与方法·························································

4、···········12结果·············································································15附图·············································································18附表·············································································21讨论····························

5、·················································24结论·············································································27参考文献·······································································28综述循环内皮细胞检测方法及其临床应用的研究进展·················31致谢·································

6、··················································43个人简历·············································································44中文摘要子宫内膜癌患者外周血循环内皮细胞的检测及其临床意义摘要目的：肿瘤新生血管的生成在肿瘤的发生、发展过程中发挥着重要的作用，其作用主要包括提供营养物质、氧以促进肿瘤的进一步生长和提供肿瘤转移、演变所需要的渠道。研究表明：循环内皮细胞（circulatingendothelialcells,CECs

7、）参与了肿瘤新生血管的生成，其机制为该细胞可以通过增殖、迁移、粘附的形式形成血管管腔。CECs进一步可分为：休眠循环内皮细胞（restingcirculatingendothelialcells,,rCECs）、活性循环内皮细胞(viablecirculatingendothelialcells，V-CECs)和凋亡循环内皮细胞（apoptoticcirculatingendothelialcells），其中V-CECs在促进肿瘤血管的生成中扮演着最重要的角色。研究报道，病情处于稳定期的肿瘤患者的外周血中CECs水平与健康人水平无明显差异，但是处于进展期的患者其