三氯化铝抑制大鼠成骨细胞的tgf-β_1smad信号转导机制

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1、中困分类号１０２２４学校代码密级公开学号１２０６１Ｑ４８１去＾《普户、聲瑚古学位论文Ｈ氯化错抑制大鼠成骨细胞的ＴＧＦ－ＶＳｍａｄｊ信号转导机制作者李森导师李艳飞教授学位类别农学硕±所在学院动物医学学院一级学科兽医学二级学科临床普医学二〇—五年六月独创声明本人声明所呈交的学位论文是本人在导师指导下进行的研巧工作及取得的研巧成果。据我所知，除了文中特别加＾＾１标注和致谢的地方外，论文中不包含其他人已经发表或撰写过的研巧成果，也不包含未获得（注＝如没有其他需要特别声

2、明的，本栏可宇）或其他教育机构的学位或证书使用过的材料一。与我同工作的同志对本研究所做的任何贡献均己在论文中作了明确的说明并表示谢意。学位论文作者签名；円期：Ｗ年４月ＩＬ０学位论文版权使用授权书本学位论文作者完全了解学校有关保留，学校有权保、使用学位论文的规定留并向国家有关部口或机构送交论文的复印件和碟盘，允许论文被查阅和借闽。本人授权学校可封将学位论文的全部或部分内容编入有关数据库进行检索，可１＾采用影印、缩印或扫描等复制手段保存、汇编学位论文。（保密的学位论文在解密后适用本授权书）：学位论文作

3、者签名：曰期＞至年＾月＾曰／导师签名；曰期：年知斗奮＾片如令Ｉ如手ClassifiedIndex：Code：10224Confidential(yes/no)：noNO.:120610481DissertationfortheMasterDegreeAlCl3InhibitstheTGF-β1/SmadPathwayofOsteoblastsinRatsCandidate:LiMiaoSupervisor:ProfessorLiYanfeiDegreeCategory:MasterofAgricultureCollege:C

4、ollegeofVeterinaryMedicineFirstleveldiscipline:VeterinaryMedicineSecondleveldiscipline:ClinicalVeterinaryMedicineHarbinChinaJune2015目录目录摘要··············································································································I英文摘要···················

5、···················································································III1前言············································································································11.1铝对骨及OB的毒性作用····························································

6、·················11.1.1铝与ALP····························································································21.1.2铝与ColI····························································································21.2铝对OB中TGF-β1/Smad信号通路的作用·····················

7、···································31.2.1TGF-β与OB························································································31.2.2TGF-β与Smad家族···············································································31.2.3TGF-β1/Smad信号转导通路与OB············

8、··················································41.2.4TGF-β1/Smad信号通路与p-JNK、p-ERK、p-p38·······