alcl3抑制大鼠骨形成及bmpsmad信号转导通路的机制

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1、优秀毕业论文CONTENTSCoNTENTSAbstractinChinese．IAbstractinEnglish．．．．．．．．．．．．．．III1lnstrction．．11．1ThetoxicityofAlonbonel1．2Alandboneformation．．21．2．1AlandB．ALP．21．2．2AlandColI．31．2．3AlandBGP．．31．3TheeffectofAlonBMP／Smadpathwayinbone．41．3．1BMP一2andboneformat

2、ion一41．3．2BMP．2andSmadfamily41．3．3BMP／Smadpathwayandboneformation41．zlNucleartranscriptionfactorandboneformation．51．4．1Runx-2andboneformation．．51．4．2Osterixandboneformation．．61．5Researehpurposeandsignificance62Materialsandmethods．．．．．．．．．．72．1Mainequi

3、pmentsandreagents72．1．1Mainequipments72．1．：!Mainreagents．．72．2Thecultureandtreatmentofrat．82．2．1Experimentalanimal82．2．2Thecollectionandtreatmentofrats．．82．3Detectingitemsandmethods82．3．1TheAllevelinserumandbone一82．3．2ThedetectionofBMD．92．3．3Thedetect

4、ionofALP，Coil，BGP,BMP-2，BMPR—IA，BM【PR-II，Smad4，Runx2，OSXmRNAexpressionsinbone．．92．3．4ThedetectionofBMP-2，p-BMPRIA，p-SmadI／5／8proteinexpressionsinbone．1l2-3．5TheeffectofAICl30np—Smadl／5／8／4proteinexpressionsinnucleusofbone112．3．6TheeffectofAlCl30nRunx2

5、，OsterixmRNAandproteinexpressionsinbone．122．4Analysisofdataandstatistics123ResultsandAnaly’sis133．1TheAllevelinserumandbone133．2TheeffectofAlCl3onBMD．．133．3TheeffectofAICl3onB-ALP,BGP,ColImRNAexpressionsinbone．14III精品参考文献资料优秀毕业论文万方数据精品参考文献资料优秀毕业论文东北农业

6、大学农学硕上学位论文3．4TheeffectofAICl3onBMP-2，BMPR·IA，BMPR—lI，Smad4mRNAexpressionsinbone153．5TheeffectofAICl3onBMP一2，p-BMPRIA，p-Smadll5／8proteinexpressionsinbone一173．6TheeffectofAICl30np-Smadl／5／8／4proteinexpressionsinnucleusofbone．．．．．．．．．．．．．．．．．．．．．183．7The

7、effectofAICl30nRunx2，OsterixmRNAandproteinexpressionsinbone．193．7．1TheeffectofAICl30nRunx2．OsterixmRNAexpressionsinbone一193．7．2TheeffectofAICl30nRunx2，Osterixproteinexpressionsinbone一204Discussion．．．．．．．．．．．214．1TheeffectofAICl3onboneformation．．．．．．．．

8、214．2TheeffectofAICl3onBMP／Smadsingalpathway．．．．．．．．224．3TheeffectofAICl30nNucleartranscriptionfactor．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．225Conclusions．．．．．．．．．．．．．．24Acknowledgement．．．．25References．26Paperspublishedi