新诊断2型糖尿病患者甲状腺功能状态临床观察

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1、授予单位代码10089学号或申请号13419瞧HebciMedicalUniversity*/硕士学位论文在职科学学位新诊断2型糖尿病患者甲状腺功能状态临床观察学位申请人：卢懿导师：李玉坤教授专业：内科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原

2、始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。,PA-wt嚴-研究生签名：导师签章二级学院领：！盖葶:/W•年月A曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章M年月2°)日目录中文摘要·························································

3、····················1英文摘要·············································································4英文缩写·············································································7研究论文新诊断2型糖尿病患者甲状腺功能状态临床观察前言···················································

4、··························9材料与方法····································································10结果·············································································16附图·············································································1

5、8附表·············································································21讨论·············································································23结论·············································································29参考文献···············

6、························································30综述2型糖尿病与甲状腺功能异常相关性的研究························34致谢···················································································40个人简历···································································

7、··········41中文摘要新诊断2型糖尿病患者甲状腺功能状态临床观察摘要目的：观察新诊断2型糖尿病（Type2diabetesmellitus，T2DM）患者与健康人群甲状腺功能状态与促甲状腺激素受体抗体（Thyroidstimulatinghormone-receptorantibodies，TRAb）的差异，分析新诊断T2DM患者不同甲状腺功能状态的临床特点，探讨在新诊断T2DM患者中筛查甲状腺功能状态与TRAb的临床意义。方法：选取2013年6月至2014年6月邢台市人民医院门诊及住院新诊断T2DM患者150

8、例，将同期100例健康体检人群设为对照组。所有受试对象空腹8小时以上，清晨抽取肘静脉血样5ml，室温静置、离心、分离血清，化学发光法检测血清三碘甲状腺原氨酸（Triiodothyronine，T3）、甲状腺素（Thyroxine，T4）、促甲状腺素（Thyroidstimulatinghormone，TSH）、游离三