多指标联合检测在小细胞肺癌诊断中的应用价值研究

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1、授予单位代码10089m学号或申请号10434HebeiMedicalUniversity硕士学位论文在职科学学位多指标联合检测在小细胞肺癌诊断中的应用价值研究学位申请人：赵维川导师：张金艳教授专业：临床检验诊断学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为河北医科大学

2、，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。研宄生签名知良叫导师签章:务/^p二级学院颔梟签章‘)ir年r月^^i贱:‘1••>•河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研宄工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人巳经发表或撰写的研究成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。研宄生签名^导师签章：丨年/月w曰目录中文摘要·································

3、············································1英文摘要·············································································2研究论文多指标联合检测在小细胞肺癌诊断中的应用价值研究前言·············································································5材料与方法·················

4、···················································5结果·············································································9附图·············································································11附表·········································

5、····································13讨论·············································································16结论·············································································19参考文献····················································

6、···················19综述肿瘤标志物在小细胞肺癌诊断中应用情况的研究进展···········21致谢···················································································30个人简历·············································································31中文摘要多指标联合检测在小细胞肺癌诊断中的应用价值研究

7、摘要目的：探讨血清肿瘤标志物CEA、NSE和ProGRP与免疫组化指标Syn、CD56、CgA，Ki-67在小细胞肺癌诊断中的关系。方法：应用电化学发光技术和化学发光技术检测48例小细胞肺癌患者血清标志物CEA、NSE和ProGRP的浓度；采用MaxVision免疫组化技术检测Syn、CD56、CgA，Ki-67；用χ2检验、两独立样本非参数检验、等级相关Spearman’s检验分析结果。结果：1小细胞肺癌免疫组化Syn、CD56、CgA表达阳性率高于血清CEA，P<0.001差异有统计学意义。免疫组化Sy

8、n、CD56、CgA表达阳性率与血清NSE、ProGRP比较，无显著性差异。2Ki-67增殖程度与血清肿瘤标志物CEA、NSE、ProGRP等浓度之间均有负相关关系，r值分别为-0.445、-0.065、-0.130；P值分别为<0.001、0.001、<0.001。P值均＜0.05有统计学意义。3局限期与广泛期免疫组化指标阳性率表达无统计学意义；广泛期血清肿瘤标志物CEA、NSE、ProGRP浓度均高于局限期，