sp1诱导的长非编码rna tincr通过调控klf2 mrna稳定性影响胃癌细胞的增殖与凋亡

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1、分类号：R73-3单位代码：10312密级：学号：20122115博士学位论文题目：SP1诱导的长非编码RNATINCR通过调控KLF2mRNA稳定性影响胃癌细胞的增殖与凋亡研究生：徐同鹏指导教师：束永前教授学科专业：肿瘤学学院名称：南京医科大学第一临床医学院完成时间：二○一五年五月巧京医科大学学位论文原创性声明本人郑重声明：所呈交的论文是本人在导师的指导下，独立进行研巧工作所取得的成果。除了文中特别加＾＾标注引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写的成果作品。对本文

2、的研究做出重要贡献的个人和。集体，均己在文中Ｗ明确方式标明本人完全意识到本声明的法律后果由本人承担。谷作者签名：曰期；年月产曰质敗导师签名ｇｇ年師棘学位文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，同意学校保留并向国家有关部口或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权南京医科大学可Ｗ将本学位论文的全部或部分内容编入有关数、据库进行检索，可功采用影印缩印或扫描等复制手段保存和汇编本学位论文。＂＂本学位论文属于（请务

3、必在下相应方框内打Ｖ）：Ｋ保密□，在＿＿年解密后适用本授权书。２、不保密口。作者签名：５知广日期：年月日茲＾多／导师签名日期：年＾月（。日Ｗ南京医科大学博士学位论文目录中文摘要·························································································1英文摘要····························································

4、·····························8前言·······················································································15第一部分：TINCR在胃癌组织及细胞系中的表达及临床意义···················171.实验材料和仪器····································································172.实验

5、方法·············································································183.结果···················································································214.讨论···············································································

6、····255.结论···················································································25第二部分：TINCR上游调控因子的检测··············································261.实验材料和仪器····································································262.实验方法······

7、·······································································283.结果···················································································354.讨论···················································································395.

8、结论···················································································39第三部分：TINCR在胃癌中的功能鉴定··············································401.实验材料和仪器··································································