nu7441对肝癌hepg2细胞放疗敏感性的影响

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1、授予单位代码10089学号或中请号20122047Hebei[MedicalUniversity硕士学位论文科学学位NU7441对肝癌HepG2细胞放疗敏感性的影响研究生：王全绪导师：杨川杰副教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下’由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河

2、北医科大学’试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：沒残导师签章：一级学院领导龜章：.》月>0河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：么>1：丧.导师签章：u年多月曰目录中文摘要······································

3、········································1英文摘要··············································································4英文缩写··············································································8研究论文NU7441对肝癌HepG2细胞放疗敏感性的影响前言················

4、······························································9材料与方法····································································10结果·············································································19附图································

5、·············································23附表·············································································30讨论·············································································31结论··········································

6、···································33参考文献·······································································33综述DNA依赖性蛋白激酶及其抑制剂与肿瘤治疗的研究进展·······37致谢···················································································48个人简历············

7、·································································49中文摘要NU7441对肝癌HepG2细胞放疗敏感性的影响摘要目的：原发性肝癌（Primarylivercancer,PLC）是一种恶性程度高、治愈率低的临床常见恶性肿瘤，居全球恶性肿瘤发病率的第六位，病死率的第三位。临床上原发性肝癌的主要治疗方法包括手术治疗、化疗、放疗、肝动脉化疗栓塞、分子靶向治疗、中医治疗等方法。由于肝癌（Hepatocellularcarcinom

8、a,HCC）的早期临床症状不明显，大部分患者就诊时已处于肝癌晚期，失去了手术机会。随着肝癌精确放疗技术的发展，放射治疗已成为晚期肝癌的主要治疗方法之一。放疗无异于电离辐射，肿瘤细胞受到射线照射后，会发生DNA损伤，损伤如果得不到及时精确地修复，就会出现细胞凋亡。肿瘤细胞具有高效的修复机制，在受到电离辐射时，细胞DNA双链断裂，继之启动修复机制。真核细胞DNA损伤主要存在两种修复方式：非同源末端连接（Nonhomologousendjoining,NHEJ