细胞因子和共刺激分子在儿童肺炎支原体肺炎发生发展中的作用

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1、授予单位代码10089学号或申请号13438HebeiMedicalUniversity硕士学位论文科学学位细胞因子和共刺激分子在儿童肺炎支原体肺炎发生发展中的作用作者姓名：庞卫花导师：赵瑞景教授专业：免疫学二级学院：基础医学院2015年03月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责

2、任。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名飞I导师签章：目录中文摘要·············································································1英文摘要·············································································4英文缩写···

3、··········································································8研究论文细胞因子和共刺激分子在儿童肺炎支原体肺炎发生发展中的作用前言·············································································9材料与方法····································································9结果···································

4、··········································19附图·············································································24讨论·············································································38结论·············································································41参考文献·······

5、································································42综述细胞因子和共刺激分子在儿童肺炎支原体肺炎发病机制中的研究············································································45致谢···················································································54个人简历·································

6、············································55中文摘要细胞因子和共刺激分子在儿童肺炎支原体肺炎发生发展中的作用摘要目的：儿童肺炎支原体肺炎（mycoplasmapneumoniaepneumonia,MPP）是当今主要的社区获得性肺炎之一，其发病率近年来有增高的趋势，并且容易引起肺外并发症，造成重症肺炎，严重威胁儿童的健康，已受到医学界的高度重视。本研究通过检测急性期、恢复期肺炎支原体肺炎患儿血清中IL-4、IFN-γ、IL-17、IL-18及共刺激分子可溶性B7-H3（sB7-H3）的水平，分析sB7-H3与细胞因子水平的相关性,评价其在肺炎

7、支原体肺炎发生发展过程中所起的作用，为肺炎支原体肺炎病情的评估、免疫干预治疗时机及干预措施的选择和预后判断提供可行的检测指标。方法：选取2013年10月至2014年10月河北北方学院附属第二医院儿科确诊为肺炎支原体肺炎的患儿,分为轻症MPP组30例、重症MPP组8例、正常对照组12例。分别采集两组MPP患儿急性期、恢复期2份血液标本以及同期正常对照组血液标本，采用酶联免疫吸附试验(ELISA)测定血清中IL-4、IFN-