肢体缺血预处理脑保护作用及上调p38 mapk和erk的体液机制

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1、授予单位代码10089学号或申请号20122624HebeiMedicalUniversity硕士学位论文科学学位肢体缺血预处理脑保护作用及上调p38MAPK和ERK的体液机制研究生:导师:孙晓彩教授专业：病理学与病理生理学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报

2、的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名:导师签章二级学院领导盖章：河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果’指导教师对此进行了审定。本论文由本人独立撰与’文责自负。研究生签名：

3、^导师签章：,災丨5年》月各j日目录中文摘要··············································································1英

4、文摘要··············································································10英文缩写··············································································22研究论文肢体缺血预处理脑保护作用及上调p38MAPK和ERK的体液机制前言··································································

5、··············23材料与方法·······································································24结果················································································36附图················································································42讨论······

6、··········································································64结论················································································67参考文献··········································································68综述急性脑缺血的研究进展··················

7、···································71致谢····················································································80个人简历··············································································81中文摘要肢体缺血预处理脑保护作用及上调p38MAPK和ERK的体液机制摘要目的：脑缺血性疾病具有发病率、致残率、死亡率高，

8、知晓率、治疗率、控制率低等特点，严重威胁着人类的生命健康。且随着我国老龄化社会的到来，此类疾病的严峻形势不容忽视。近年来，许多科研人员致力于调动机体内源性保护机制以提高脑神经细胞对缺血性损害的抵抗力的研究，使其在遭受严重的缺血打击并恢复血液灌流后仍具有正常的生理功能，为此类疾病的防治提供新思路。自1990年日本学者Kitagawa发现脑缺血预处理现象以来，大量研究证实了同一器官缺血预处理所带来的保护作用。尽管脑缺血预处理诱导的脑缺血耐受具有强大的内源性保护作用，然而对中枢器官进行缺血预处理，很难作为一种脑缺血前的预防措施直接应用于临床

9、。随着对缺血预处理研究的进一步深入，许多研究者发现并证实了远隔器官缺血预处理的保护作用。远隔器官缺血预处理是指预先对靶器官以外的组织或器官进行缺血预处理，使靶器官产生缺血耐受的现象。这一发现实现了采用非重要生命器官缺血预