微骨折技术结合富血小板血浆治疗兔膝关节软骨损伤的生物力学研究

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1、授予单位代码10089学号或申请号20122243X妗(I科大坌HebeiMedicalUniversity硕士学位论文科学学位微骨折技术结合富血小板血浆治疗兔膝关节软骨损伤的生物力学研究研究生：王亚博导师：髙石军教授专业：外科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大

2、学，试验材料、原始数据、申报的专利等知识产权归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签名河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要················································································1英文摘要············

3、····································································4英文缩写················································································8研究论文微骨折技术结合富血小板血浆治疗兔膝关节软骨损伤的生物力学研究前言·············································································

4、··9材料与方法······································································10结果···············································································13附图··············································································15附表····················

5、···························································23讨论···············································································24结论···············································································29参考文献····································

6、····································29综述关节软骨损伤的治疗研究进展··········································32致谢·····················································································42个人简历·············································································

7、·43中文摘要微骨折技术结合富血小板血浆治疗兔膝关节软骨损伤的生物力学研究摘要目的：关节软骨的损伤是目前临床上非常常见的膝关节疾病。运动损伤、肥胖、年龄等是其发生与发展的重要因素。然而，关节软骨并没有来自血管的血液供应及神经支配，其再生长能力极弱，一旦损伤很难恢复。当关节软骨遭到破坏后，软骨损伤可通过以下途径进一步加剧：一方面：胫股关节缺乏足够的应力，损伤的软骨不能通过适当的形变分配受力并汲取营养，进而导致受力分布不均、细胞功能下降；另一方面：粘蛋白聚糖从组织中逸出，从而导致软骨硬度的变化，增加软骨发生损伤的几率，而这些风险在正

8、常关节的承重活动中即可发生。由于软骨的生物力学性质明显取决于其成分组成和正常的超微结构，其生物力学的测量是对软骨修复术后软骨机械性能及结构组成的间接反映。因此，同软骨的组织学特性相比，其生物力学特性的恢复同样非常重要。目前临床关于关节软骨损伤的治疗可分为是否修复