左卡尼汀对老年非st段抬高型心肌梗死患者内皮素和脑钠肽水平的影响

《左卡尼汀对老年非st段抬高型心肌梗死患者内皮素和脑钠肽水平的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号13516HebeiMedicalUniversity硕士学位论文在职科学学位左卡尼汀对老年非ST段抬高型心肌梗死患者内皮素和脑钠肽水平的影响学位申请人：周志安导师：局嘉教授专业：内科学二级学院：第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研宄成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报

2、的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研宄工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研宄成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要·············································································1英文摘要·········································

3、····································3研究论文左卡尼汀对老年非ST段抬高型心肌梗死患者内皮素和脑钠肽水平的影响前言·············································································5材料与方法····································································6结果···········································

4、··································8附图·············································································11附表·············································································12讨论·········································································

5、····14结论·············································································19参考文献·······································································19综述非ST段抬高型心肌梗死与内皮素和脑钠肽水平的相关性······23致谢·······································································

6、············40个人简历·············································································41中文摘要左卡尼汀对老年非ST段抬高型心肌梗死患者内皮素和脑钠肽水平的影响摘要目的：急性冠脉综合征（acutecoronarysyndrome，ACS）包括不稳定型心绞痛（unstableangina，UA）、非ST段抬高型心肌梗死（non-ST-elevatedmyocardialinfarction，NSTEMI）和ST段抬高型心肌梗死（ST-e

7、levatedmyocardialinfarction，STEMI），临床上对于ACS的生化诊断标志物已经进行了大量的研究。本文主要探讨左卡尼汀对老年NSTEMI患者内皮素(Endothelin-1,ET-1)和脑钠肽(brainnatriureticpeptide,BNP)水平的影响，旨在为NSTEMI的诊治提供新的理论依据。方法：选择2013-10～2014-08在发病后6小时内入住承德市中心医院老年病科和心内科、入院后确诊为NSTEMI的年龄大于60岁的患者60例作为治疗组，随机分为左卡尼汀组（A组）和常规治疗组（B组），所有患者入

8、院后即刻及入院后分别在发病6h、12h、24h、3d、7d、14d六个时段均留取血标本测定血清ET-1及BNP水平。选择承德市中心医院健康体检中心体检健康的60周岁以上老年人30例作为对照组。