不同糖耐量人群血浆同型半胱氨酸水平与尿白蛋白排泄率的相关性研究

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1、授予单位代码誦９ｖｌｌ＾ａＰｌｙ学号或申请号１３４４４巧作忘钟＞、适ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位不同糖耐量人群血浆同型半脱氨酸水平与尿白蛋白排泄率的相关性研究学位申请人：刘莉芳导师：马博清教授专业：内科学二级学院：河北省人民医院２０１５年１０月＇■ｉ、占．河北医科大学学位论文使用授权及知识产权归属承诺？本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果

2、，其知识产权旧河北長科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表一署名为单位河北医科大学与学位论文主要内容相关的论文，第，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。。否则，承担相应法律责任ｒＴ：＾研究生签名．＾：；＾导师签章＾绣警院！１＾＼＾调＾＾＾＾＾曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行

3、了审定。本论文由本人独立撰写，文责自负。研究生签名：刮导师签章：ｉ。ｈ．ｒ年ｆｉ月＾日目录中文摘要··············································································1英文摘要··············································································4英文缩写·····································

4、·········································7研究论文不同糖耐量人群血浆同型半胱氨酸水平与尿白蛋白排泄率的相关性研究前言··············································································9材料与方法·····································································10结果·························

5、·····················································13附表··············································································15讨论··············································································18结论········································

6、······································21参考文献········································································21综述同型半胱氨酸与糖尿病肾病关系的研究进展·························25致谢····················································································35个人简历···

7、···········································································36中文摘要不同糖耐量人群血浆同型半胱氨酸水平与尿白蛋白排泄率的相关性研究摘要目的：通过对不同糖耐量人群血浆同型半胱氨酸（Hcy）及尿白蛋白排泄率（UAER）水平测定，来研究判断血浆Hcy是否是UAER升高的危险因素，从而为防止糖尿病肾病（DN）的发生和延缓进展提供新思路。方法：选择2014年1月到2014年12月在河北省保定市第一中心医院就诊的住院及门诊患者。清晨空腹

8、状态下行口服75g无水葡萄糖耐量试验（OGTT）,按照1999年世界卫生组织（WHO）关于2型糖尿病（T2DM）诊断标准进行分类，42例新诊断的T2DM尚未用药者即新发糖尿病组（DM组），32例糖调节受损者组成糖调节受损组（IGR组），38例血糖正常者组成糖耐量正常组（NGT组）。调查上述受试者的一般临床资料，包括性别、年龄、吸烟史、饮酒史、既