不同糖代谢状态人群血清游离脂肪酸与甲状腺功能状态的相关性研究

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1、授予单位代码１００８９１学号或申请号１３４１４巧（Ｅ钟Ａ達ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位不同糖代谢状态人群血清游离脂肪酸与甲状腺功能状态的相关性研究学位申请人：路玉李导师：宋光耀教授任路平副教授专业：内科学二级学院：河北省人民医院２０１５年１０月河北医科大学学位论文使用授巧及知巧产枚归承诺＾本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学

2、所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表一与学位论文主要内容相关的论文，第署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。、研巧生签名；义今导师签二级学院领＾％，鄭Ｊ策河北医科大学研究生学位论文独创性青明本论文是在导师指导下进行的研巧工作及取得的硏究成果，除了文中特别加科标注和致谢等内容外，文中不包含其他人己经发表或撰写的研巧成果。本论文由本人独立撰写，，指导教师对此迸行了审定文责自负。研究

3、生签名；导师签章：。＇／月Ｗ年；曰＇■—：．‘＇＇■－，＇■＇：目录中文摘要··············································································1英文摘要··············································································4英文缩写·······································

4、·······································8研究论文不同糖代谢状态人群血清游离脂肪酸与甲状腺功能状态的相关性研究前言··············································································9材料与方法·····································································9结果································

5、··············································12附图··············································································10附表··············································································14讨论··················································

6、····························17结论··············································································19参考文献········································································20综述游离脂肪酸与甲状腺功能状态的研究进展···························22致谢·······················

7、·····························································32个人简历··············································································33中文摘要不同糖代谢状态人群血清游离脂肪酸与甲状腺功能状态的相关性研究摘要目的：随着我国经济的快速发展，居民的膳食结构发生了很大的改变，脂肪类食物的摄入超标，糖脂代谢异常成为普遍现象。我们前期的研究发现在糖代谢异常的患者血中游离脂肪酸升

8、高，特别是饱和脂肪酸的增多更加明显。游离脂肪酸的增多对促进胰岛素抵抗的形成起到了重要作用，深入研究游离脂肪酸增加的因素，对改善糖代谢异常和胰岛素抵抗有重要意义。近年来对甲状腺功能的研究显示，甲状腺激素的水平可以影响脂代谢的调节。甲状腺功能减退（甲减）患者出现血胆固醇水平的升高等血脂异常已被大家所认识，单