超敏c反应蛋白、降钙素原及白细胞计数在新生儿感染诊断价值比较

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1、授予单位代码10089学号或申请号13137HebeiMedicalUniversity硕士学位论文科学学位超敏C反应蛋白、降钙素原及白细胞计数在新生儿感染诊断价值比较作者姓名：闫学爽导师：李月梅教授专业：儿科专业二级学院：河北医科大学第二医院2015年03月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关

2、的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章厂年JT月？CP曰目录中文摘要······················································

3、·······················1英文摘要·············································································3研究论文超敏C反应蛋白、降钙素原及白细胞计数在新生儿感染诊断价值比较前言·············································································6材料与方法··························

4、··········································8结果·············································································11附图·············································································13附表············································

5、·································14讨论·············································································16结论·············································································22参考文献··················································

6、·····················22综述新生儿感染诊断指标的研究进展······································27致谢···················································································36个人简历·············································································37中文

7、摘要超敏C反应蛋白、降钙素原及白细胞计数在新生儿感染诊断价值比较摘要目的:探讨超敏C反应蛋白（hs-CRP）、血清降钙素原（PCT）和白细胞（WBC）计数在新生儿感染早期的快速诊断和治疗价值。方法：研究对象：选自2014年1月～2015年1月期间我院新生儿科收住的日龄0～28天，出生胎龄37～40周，出生体重2500～4000g之间的足月新生儿。按照临床表现及实验室检测结果分为（1）全身感染组（败血症组）20例：其中血培养阳性的确诊败血症10例，临床诊断败血症8例，败血症合并化脓性脑膜炎2例；（2

8、）局部感染组20例：包括单纯性肺炎10例、脓疱疹3例、脐炎4例、细菌性肠炎2例及尿路感染1例，均为仅1个部位感染；（3）非感染组40例：包括新生儿咽下综合征10例，新生儿黄疸20例，新生儿湿肺10例。三组患儿在男女比例、胎龄、体重、日龄方面均无统计学意义。标本采集：感染组患儿于入院当天和恢复期（入院第7天）分别采集股静脉血2ml，检测血白细胞计数和分类，hs-CRP和PCT，入院接受抗生素治疗前取股静脉血1.5ml做病原学检测，肺炎患儿留取呼吸道分泌物做培养，脐炎、脓疱疹、肠炎、尿