胆汁酸对梗阻性黄疸肠黏膜屏障的保护作用及其机制的研究

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1、授予单位代码10089学号或申请号20121034HebeiMedicalUniversity博士学位论文胆汁酸对梗阻性黄疸肠黏膜屏障的保护作用及其机制的研究研究生：纪晨光导师：姜慧卿教授专业：内科学二级学院：第二医院2015年4月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原

2、始数据、申报的专利等知识产权归河北医科大学所有。否则，承担相应的法律责任。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包括其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名导师签章目录中文摘要··············································································1英文摘要·················

3、·····························································6英文缩写·············································································14研究论文胆汁酸对梗阻性黄疸肠黏膜屏障的保护作用及其机制的研究引言·············································································16第一部分

4、胆汁对梗阻性黄疸患者肠黏膜屏障的作用及TGR5表达的影响前言·············································································18材料与方法····································································19结果··········································································

5、···31附图·············································································33附表·············································································39讨论·············································································41小结··········

6、···································································43参考文献·······································································44第二部分胆汁酸对梗阻性黄疸大鼠肠黏膜屏障的作用及TGR5表达的影响前言·············································································47

7、材料与方法····································································48结果·············································································60附图·············································································62附表·····················

8、························································65讨论·············································································66小结·······································