河北地区汉族人群人类血小板同种抗原等位基因频率研究

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1、授予单位代码10089学号或申请号13604HebeiMedicalUniversity在职科学学位河北地区汉族人群人类血小板同种抗原等位基因频率研究学位申请人：李茵导师：马翠卿教授专业：免疫学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料

2、、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：导师签章:级学院领导盖章：W年J月f日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：4^)导师签章：74^y月豕日目录中文摘要·······················································

3、····················································1英文摘要···········································································································4研究论文河北地区汉族人群人类血小板同种抗原等位基因频率研究前言·····························································

4、··············································8材料与方法·······························································································9结果·········································································································13

5、附图·········································································································15附表·········································································································21讨论·····································

6、····································································26结论·········································································································30参考文献··········································································

7、·······················31综述人类血小板抗原基础及研究进展·····················································33致谢·················································································································43个人简历········································

8、·································································44河北地区汉族人群人类血小板同种抗原等位基因频率研究摘要目的：人类血小板特异性同种异体抗原（humanplatelet-specificalloantigen，HPA）是由血小板糖蛋白携带的，主要位于人血小板细胞膜的一大类抗原，其基因具有单一核苷酸多态性（singlen