慢性乙型病毒性肝炎患者血清il-27水平及其临床意义

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1、授予单位代码10089学号或申请号13328HebeiMedicalUniversity硕士学位论文在职科学学位慢性乙型病毒性肝炎患者血清IL-27水平及其临床意义学位申请人：王学敏导师：甄真教授专业：内科学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大

2、学所有。否则,承担相应法律责任。研究生签名：_导师签章二级学院领导盖章：/A>'r年J月？曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章：穴江年丄月日目录中文摘要·············································································1英文摘要···············

3、······························································4英文缩写·············································································8研究论文慢性乙型病毒性肝炎患者血清IL-27水平及其临床意义前言·············································································10材料与方法················

4、····················································11结果·············································································15附表·············································································18讨论···························································

5、··················21结论·············································································25参考文献·······································································25综述IL-27在乙型病毒性肝炎病情进展及治疗中的作用·················28致谢····················································

6、·······························38个人简历·············································································39中文摘要慢性乙型病毒性肝炎患者血清IL-27水平及其临床意义摘要目的：检测HBV感染患者不同病程阶段(包括慢性乙型肝炎（CHB）、肝硬化（LC）及慢加急性肝衰竭（ACLF））血清IL-27变化，分析其血清IL-27变化与IFN-γ、肝功能检测指标及HBV免疫学指标等之间的关系，从而探讨IL-27在CHB病情进展中的作用，

7、为IL-27应用于临床CHB病情监测及指导用药提供科学依据。方法：1研究对象：CHB患者89例，其中轻度组（lightchronichepatitisB,CHB-l）31例，中度组（moderatechronichepatitisB,CHB-m）51例，重度组（severechronichepatitisB,CHB-s）7例；HBV感染相关肝硬化（livercirrhosis,LC）患者41例（代偿期（compensatorylivercirrhosis,LC-c）患者12例，失代偿期（decompensatorylivercirrhosis,LC

8、-d）患者29例）；HBV感染相关慢加急性肝衰竭（acute-on-chronicliverfailure,ACLF）患者