京尼平苷酸抗佐剂性关节炎大鼠滑膜细胞炎症及其mapk信号转导通路的机制研究

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1、授予单位代码10089学号或申请号11201HebeiMedicalUniversity硕士学位论文在职科学学位京尼平苷酸抗佐剂性关节炎大鼠滑膜细胞炎症及其MAPK信号转导通路的机制研究学位申请人：杨丽颖导师：朱江教授专业：药理学二级学院：武警后勤学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医

2、科大学所有。否则,承担相应法律责任。：-r••：I':ri1•‘‘；*.•*s1色^‘-r••飞V:tJ/*L•yr---<•-‘••：研究生签名导师签章:一•级学院领等叢章：：:識年關_日W/YY^1L.m./、“(河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：於級导师签章：年女月Jo目录中文摘要····················································

3、·························1英文摘要·············································································4英文缩写·············································································7研究论文京尼平苷酸抗佐剂性关节炎大鼠滑膜细胞炎症及其MAPK信号转导通路的机制研究前言································································

4、·············9材料与方法····································································9结果·············································································22附图·············································································26附表·············································

5、································35讨论·············································································36结论·············································································38参考文献·······································································38综述临床常用治疗类风湿性关节炎药物的作用机制及不

6、良反········42致谢···················································································51个人简历·············································································52中文摘要京尼平苷酸抗佐剂性关节炎大鼠滑膜细胞炎症及其MAPK信号转导通路的机制研究摘要目的：类风湿关节炎(rheumatoidarthritis，RA)是一种以累及周围关节为主的多系统慢性自身免疫性疾病，以滑膜组织炎性增生、关节软

7、骨进行性破坏为特征。该病遍布世界各地，各个种族均有发病。RA的传统治疗药物主要包括非甾体类抗炎药、抗风湿药、糖皮质激素、植物药、肿瘤坏死因子α拮抗剂等几大类。目前临床上应用的药物主要用于控制和缓解RA症状，且存在较多的不良反应，所以寻找高效低毒治疗RA的新药是今后研究的重要方向。我们前期研究发现，中药栀子具有显著抗炎镇痛作用，栀子浸膏及其单体京尼平苷酸明显抑制RA大鼠足肿胀，提示该药物对治疗RA有较好的作用前景。其中京尼平苷酸(ge