ω-3多不饱和脂肪酸对腹部脓毒症患者的治疗作用研究

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1、授予单位代码10089学号或申请号20122193对妗(E搿大交HebeiMedicalUniversity硕士学位论文科学学位co-3多不饱和脂肪酸对腹部脓毒症患者的治疗作用研究研究生：刘志宽导师：佟飞教授专业：急诊医学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、

2、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名:声师签章：二级学院领•章4承月少日：河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：年>月P日目录中文摘要············································································

3、····1英文摘要················································································3英文缩写················································································5研究论文ω-3多不饱和脂肪酸对腹部脓毒症患者的治疗作用研究前言·································································

4、···············6材料与方法·······································································7结果··············································································10附图··············································································12附表············

5、··································································16讨论··············································································23结论··············································································26参考文献···································

6、·····································27综述ω-3多不饱和脂肪酸的研究进展及临床应用现状···················30致谢····················································································42个人简历··············································································43中文摘要ω-3多不饱和脂肪酸对

7、腹部脓毒症患者的治疗作用研究摘要目的：随着科学的进步，对脓毒症的病因及发病机制有了更深的研究与探索。脓毒症是临床急危重症患者主要死亡原因之一，发病机制复杂，目前认为不仅与原发疾病有关，还与细菌内毒素、炎症反应、凝血功能异常、神经及内分泌调节失衡、免疫功能紊乱、肠道细菌易位及基因多态性等方面密切相关。近年来研究表明，免疫调节功能紊乱是脓毒症重要的病理生理改变，且在脓毒症致多脏器功能障碍（multipleorgandysfunctionsyndrome，MODS）时尤其显著，直接影响着疾病的发生、发展及预后。因此，通过免疫营养调理全身性感染

8、、恢复促炎与抗炎的平衡成为脓毒症诊疗新思路。ω-3多不饱和脂肪酸（ω-3polyunsaturatedfattyacids，ω-3PUFAs)是重要的免疫营养素，不仅能为机体提供能量和代谢底物，还可以调控机