x-射线照射后a549细胞释放的exosome对同源细胞及巨噬细胞功能的影响

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1、授予单位代码顯９＿＿学号或申请号１３７９０＂巧Ｗ（￡钟夫這ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位Ｘ－射线照射后Ａ５４９细胞释放的ｅｘｏｓｏｍｅ对同源细胞及巨瞻细胞功能的影响学位申请人；杨燕导师；宋淑霞教授专业；免疫学二级学院：基础医学院２０１５年１０月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位

2、论文迸行交流、公开巧使用。凡发表一与学位论文主要內容相关的论文，第署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。￣研究生签名：＾＾＾爲师签章：采翁良二级学院领导盖章南春＾ＩＩ４Ｉ巧郑／日■ｉ河北医科大学硏究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加臥标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名；导师签章：

3、厂年／Ｚ月ｙ日目录中文摘要··············································································1英文摘要··············································································4英文缩写··············································································7研究论文X-射线照射后A549

4、细胞释放的exosome对同源细胞及巨噬细胞功能的影响前言··············································································8材料与方法·····································································8结果··············································································18附图··········

5、····································································20附表··············································································16讨论··············································································25结论·········································

6、·····································26参考文献········································································26综述肿瘤释放的外泌体影响肿瘤进展和转移·······························29致谢····················································································38个人简历················

7、······························································39中文摘要X-射线照射后A549细胞释放的exosome对同源细胞及巨噬细胞功能的影响摘要目的：放疗是治疗肿瘤的有效方法之一，但临床上发现放疗后循环肿瘤细胞（circulatingtumorcells,CTCs）数目增加，并通过循环肿瘤细胞造成肿瘤的复发和转移。目前认为肿瘤细胞分泌的外泌体（TumorDerivedExosome，TD-exosomes）可参与并促进肿瘤的发生、发展，但放疗后残存肿瘤细胞分泌的外泌体的功能是否

8、发生改变，即对肿瘤细胞及基质细胞的作用还鲜有报道。本实验采用A549细胞释放的exosome（A549/exo）和X-射线