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ID:34864631
大小:2.58 MB
页数:42页
时间:2019-03-12
《x-射线照射后a549细胞释放的exosome对同源细胞及巨噬细胞功能的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、授予单位代码顯9__学号或申请号13790"巧W(£钟夫這HebeiMedicalUniversity硕±学位论文在职科学学位X-射线照射后A549细胞释放的exosome对同源细胞及巨瞻细胞功能的影响学位申请人;杨燕导师;宋淑霞教授专业;免疫学二级学院:基础医学院2015年10月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下,由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位
2、论文迸行交流、公开巧使用。凡发表一与学位论文主要內容相关的论文,第署名为单位河北医科大学,试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。 ̄研究生签名:^^^爲师签章:采翁良二级学院领导盖章南春^II4I巧郑/日■i河北医科大学硏究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加臥标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名;导师签章:
3、厂年/Z月y日目录中文摘要··············································································1英文摘要··············································································4英文缩写··············································································7研究论文X-射线照射后A549
4、细胞释放的exosome对同源细胞及巨噬细胞功能的影响前言··············································································8材料与方法·····································································8结果··············································································18附图··········
5、····································································20附表··············································································16讨论··············································································25结论·········································
6、·····································26参考文献········································································26综述肿瘤释放的外泌体影响肿瘤进展和转移·······························29致谢····················································································38个人简历················
7、······························································39中文摘要X-射线照射后A549细胞释放的exosome对同源细胞及巨噬细胞功能的影响摘要目的:放疗是治疗肿瘤的有效方法之一,但临床上发现放疗后循环肿瘤细胞(circulatingtumorcells,CTCs)数目增加,并通过循环肿瘤细胞造成肿瘤的复发和转移。目前认为肿瘤细胞分泌的外泌体(TumorDerivedExosome,TD-exosomes)可参与并促进肿瘤的发生、发展,但放疗后残存肿瘤细胞分泌的外泌体的功能是否
8、发生改变,即对肿瘤细胞及基质细胞的作用还鲜有报道。本实验采用A549细胞释放的exosome(A549/exo)和X-射线
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