twist基因诱导绒癌细胞上皮—间质转化的研究

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1、s授予单位代码10089学号或申请号20122271HebeiMedicalUniversity硕士学位论文科学学位Twist基因诱导绒癌细胞上皮-间质转化的研究研究生：马丹丹导师：庞义存教授专业：妇产科学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有

2、。否则，承担相应法律责任。研究生签名导师签章:二级学院领导盖章：月方日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：名拼导师签章：年3月《日目录中文摘要·················································································1英文摘要·······················

3、··························································4英文缩写···············································································9研究论文Twist基因诱导绒癌细胞上皮-间质转化的研究前言··············································································10材料与方法······················

4、···············································11结果··············································································23附图··············································································25附表································································

5、··············28讨论··············································································30结论··············································································33参考文献········································································34综述Twist基因与妇科恶性肿瘤上皮-间质

6、转化的研究进展··············38致谢·····················································································45个人简历···············································································46中文摘要Twist基因诱导绒癌细胞上皮-间质转化的研究摘要目的：绒毛膜癌（choriocarcinoma）简称绒癌(CC)，在妊娠滋养细胞疾病中（gestation

7、altrophoblasticdisease，GTD）恶性程度居于首位。其可继发于包括足月分娩、异位妊娠、自然流产以及葡萄胎在内的各种类型的妊娠。绒癌在女性生殖系统肿瘤中发病率虽不及宫颈癌、卵巢癌及子宫内膜癌，但其发展迅速，早期即可转移至肺、脑等重要脏器，恶性程度极高，严重危害着广大女性的生命健康。因其对化疗药物极其敏感，绒癌成为首个能够通过化疗治愈的妇科实体肿瘤。但由于化疗药物种类及化疗方案的选择不当，常导致肿瘤细胞耐药的情形产生，使之成为化疗失败的最主要原因。滋养细胞肿瘤的发病与多方面因素有关，发病机制尚未明确，因此关于其发生、发展及耐药方面的研究

8、一直是人们广泛关注的话题。现已证实上皮-间质转化(epithelialmesenchymalt