epo联合心脉隆辅助治疗慢性充血性心力衰竭合并贫血的临床观察

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1、授予单位代码10089学号或申请号13928HebeiMedicalUniversity士学位论文在职科学学位EPO联合心脉隆辅助治疗慢性充血性心力衰竭合并贫血的临床观察学位申请人：周立宾导师：魏庆民教授专业：内科学二级学院：邢台市人民医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一

2、署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则应法律责任。/i.拓A、河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研宄工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研宄成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名年！^月M目录中文摘要······································································

3、·······1英文摘要·············································································4英文缩写·············································································9研究论文EPO联合心脉隆辅助治疗慢性充血性心力衰竭合并贫血的临床观察前言··············································

4、·······························10材料与方法····································································11结果·············································································13附表·······························································

5、··············15讨论·············································································18结论·············································································20参考文献·······································································2

6、1综述慢性充血性心力衰竭的临床研究······································24致谢···················································································31个人简历·············································································32中文摘要EPO联合心脉隆辅助治疗慢性充血性心力衰竭合并

7、贫血的临床观察摘要目的：慢性充血性心力衰竭(CHF)是大多数心血管疾病的最终结局,其发病机制复杂,现认为主要与心室结构重建、各种体液细胞因子激活及神经内分泌紊乱有关。CHF在发生发展过程中常并发贫血，其严重程度与CHF相关，被看成CHF预后不良的预测因子，故纠正贫血对于CHF治疗有积极作用。本研究旨在观察EPO联合心脉隆注射液辅助治疗慢性充血性心力衰竭合并贫血的临床疗效和不良反应,评价两药临床应用的有效价值和安全性。方法：1研究对象选取邢台市人民医院心内科2013年10月至2015年1月住院的CHF合并

8、轻度贫血患者。纳入标准：（1）符合CHF的诊断标准，参照2002年中国《慢性收缩性心力衰竭诊断治疗指南》,主要表现是呼吸困难、四肢无力、纳差和水肿等，结合病史、体格检查、超声心动图、胸部X线片、BNP等作出明确诊断。（2）成年人；左室舒张末期内径（LVEDD）增大；男性>55mm，女性>50mm；静息状态下左室射血分数（LVEF）≤40%；Hb浓度男性大于90g/L，低于120g/L；女性大于90g/L，低于110g/L。（3）愿意配合治疗