dna修复通路基因多态位点与乳腺癌发病风险在中国北方汉族女性人群中的遗传关联研究

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1、授予单位代码10089学号或申请号20120008蚵妗(E科大空HebeiMedicalUniversity临床医学博士学位论文DNA修复通路基因多态位点与乳腺癌发病风险在中国北方汉族女性人群中的遗传关联研究作者姓名：丁佩剑导师：蔡建辉教授专业：临床医学二级学院：河北省人民医院2015年4月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名

2、单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北有。否则，承担相应的法律责任。研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人已发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：z导师签章:目录中文摘要··············································································1英文摘要························

3、······················································5英文缩写·············································································10研究论文DNA修复通路基因多态位点与乳腺癌发病风险在中国北方汉族女性人群中的遗传关联研究引言·············································································11第一部分5个DNA修复基

4、因与乳腺癌发病关系的单基因多态性分析前言·············································································14材料与方法····································································14结果·············································································24附表··················

5、···························································26讨论·············································································29小结·············································································30第二部分5个DNA修复基因7个多态位点对乳腺癌发病风险的预测前言····················

6、·························································31材料与方法····································································31结果·············································································34附图··························································

7、···················37附表·············································································41讨论·············································································44小结·············································································45第三部分5个DNA修复

8、基因7个多态位点联合作用与乳腺癌发病风险的研究前言··················································