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1、PublishedOnlineFirstonAugust18,2011;DOI:10.1158/0008-5472.CAN-11-0073MicroRNA-708InducesApoptosisandSuppressesTumorigenicityinRenalCancerCellsSharanjotSaini,SoichiroYamamura,ShahanaMajid,etal.CancerResPublishedOnlineFirstAugust18,2011.UpdatedVersionAccessthemostrece
2、ntversionofthisarticleat:doi:10.1158/0008-5472.CAN-11-0073SupplementaryAccessthemostrecentsupplementalmaterialat:Materialhttp://cancerres.aacrjournals.org/content/suppl/2011/08/18/0008-5472.CAN-11-0073.DC1.htmlE-mailalertsSignuptoreceivefreeemail-alertsrelatedtothis
3、articleorjournal.ReprintsandToorderreprintsofthisarticleortosubscribetothejournal,contacttheAACRSubscriptionsPublicationsDepartmentatpubs@aacr.org.PermissionsTorequestpermissiontore-useallorpartofthisarticle,contacttheAACRPublicationsDepartmentatpermissions@aacr.org
4、.Downloadedfromcancerres.aacrjournals.orgonSeptember22,2011Copyright©2011AmericanAssociationforCancerResearchPublishedOnlineFirstonAugust18,2011;DOI:10.1158/0008-5472.CAN-11-0073CancerMolecularandCellularPathobiologyResearchMicroRNA-708InducesApoptosisandSuppressesT
5、umorigenicityinRenalCancerCellsSharanjotSaini,SoichiroYamamura,ShahanaMajid,VarahramShahryari,HiroshiHirata,YuichiroTanaka,andRajvirDahiyaAbstractCancerpathogenesisisrestrictedbystressesthatcompromisecelldivisionandsurvival.Inthisstudy,weidentifymiR-708,alittlestudi
6、edmemberofasetofmicroRNAsthathavebeenimplicatedinstresscontrol,asanimportanttumorsuppressorinrenalcellcarcinoma(RCC).miR-708expressionwasattenuatedwidelyinhumanRCCspecimens.RestorationofmiR-708expressioninRCCcelllinesdecreasedcellgrowth,clonability,invasion,andmigra
7、tionandelicitedadramaticincreaseinapoptosis.Moreover,intratumoraldeliveryofmiR-708wassufficienttotriggerinvivoregressionofestablishedtumorsinmurinexenograftmodelsofhumanRCC.InvestigationofthetargetsofmiR-708identifiedtheinhibitorofapoptosisproteinsurvivinasimportant
8、.siRNA-mediatedknockdownofsurvivinpartiallyphenocopiedmiR-708overexpressionsuggestingthattheproapoptoticroleofmiR-708maybemediatedprimaril
