MicroRNA-133a调控PI3K_AKT_mTOR信号通路参与哮喘气道重塑的机制研究

《MicroRNA-133a调控PI3K_AKT_mTOR信号通路参与哮喘气道重塑的机制研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、温州医科大学博士学位论文分类号:R72单位代码：10343学号：142002007博士学位论文论文题目:MicroRNA-133a调控PI3K/AKT/mTOR信号通路参与哮喘气道重塑的机制研究研究生姓名：邵优优学科专业：儿科学类型：学术型指导教师：李昌崇二O一八年五月温州医科大学博士学位论文论文题目:MicroRNA-133a调控PI3K/AKT/mTOR信号通路参与哮喘气道重塑的机制研究答辩委员会主席：张建华教授上海交通大学医学院附属新华医院答辩委员会成员：吕海涛教授苏州大学附属儿童医院王良兴教授温州医科大

2、学附属第一医院褚茂平教授温州医科大学附属育英儿童医院吴丽慧教授浙江省人民医院论文答辩日期：2018年5月20日温州医科大学博士学位论文目录全文缩略词表····································································1中文摘要··········································································3英文摘要·······························

3、···········································9前言··············································································17第一部分microRNA-133a在哮喘中表达的变化及其对哮喘气道重塑的影响···········································································23第二部分miR-133a调控PI3

4、K/AKT/mTOR表达改善哮喘气道重塑····················································································44第一章PI3K/AKTmTOR信号通路在哮喘中的作用···················44第二章microRNA-133a对PI3K/AKT/mTOR信号通路的调控作用53第三部分miR-133a直接作用于靶基因IGF1R·························58参考文献········

5、································································63附录图···········································································69全文研究结论··································································88今后研究方向································

6、··································88致谢··············································································90综述··············································································91学位论文独创性申明·················································

7、·······101温州医科大学博士学位论文全文缩略词表英文缩写英文全称中文译名ASMCsAirwaysmoothmusclecells气道平滑肌细胞TGF-βTransforminggrowthfactorbeta转化生长因子VEGFVascularendothelialgrowthfactor血管内皮生长因子IL-6Interleukin6白介素6VEGFVascularendothelialgrowthfactor血管内皮生长因子RTKReceptortyrosinekinase酪氨酸激酶受体GPCRGp

8、roteincoupledreceptorG蛋白偶联受体MAPKMitogen-activatedproteinkinase丝裂素活化蛋白激酶mTORMammaliantargetofrapamycin哺乳动物雷帕霉素靶蛋白RaptorRegulatory-associatedproteinof雷帕霉素靶蛋白调节相关mammaliantargetofrapamycin蛋白RictorR